摘要
目的介绍上皮-间质转化(EMT)在胃肠道肿瘤中的研究现状。方法收集近年来国内、外有关EMT及其调节因子与胃肠道肿瘤关系的文献并作综述。结果 EMT是胚胎发育的一个基本过程,在成熟上皮细胞中EMT的异常激活可以降低细胞间黏附分子表达进而促进肿瘤的转移。上皮细胞表面标志物E-钙黏素表达抑制和EMT发生密切相关,E-钙黏素转录抑制因子可能在调节EMT过程中起重要作用,并且这些转录抑制因子在胃肠道肿瘤中呈明显高表达。此外,EMT的发生可能在胃肠道肿瘤干细胞形成过程中起重要作用。结论 EMT及其调节因子在胃肠道肿瘤发生、侵袭和转移过程中起了重要作用,对于EMT及其调节因子的研究可以为肿瘤发生机理提供新的视角,为肿瘤治疗提供新的靶点。
Objective To summarize the role of epithe lial-mesenchymaltransition（EMT） in occurrence and development of gastrointestinal cancer. Methods Domestic and international publications online involvi ng EMT of gastroin testinal cancer in recent years were collected and reviewed.Results EMT was a highly conserved process that has been well characterised in embryogenesis.S tudies had shown that the aberrant activation of EMT in adult epithelia could pr omote tumour metastasis by repressing cell adhesion molecules.E-cadherin,one of the epithelial cell markers,maybe involved in the process of the EMT,espe cially of the E-cadherin transcriptional repressors,these transcriptional rep r essors significantly increased in the gastrointestinal cancer.Further more,E MT might involve in the process of gastrointestinal cancer stem cells formation. Conclusions EMT and it＇s regulators play a very important role in gastrointest inal cancer,and may provide a newsight into the gastrointestinal cancer.It a lso can provide a novel clinical targets to treat the gastrointestinal cancer.
出处
《中国普外基础与临床杂志》
CAS
2011年第11期1234-1236,F0003,共4页
Chinese Journal of Bases and Clinics In General Surgery
基金
上海市科委基金资助项目(项目编号:09411962300)
上海市卫生局基金资助项目(项目编号:2010018)~~
关键词
上皮-间质转化
E-钙黏素
消化道
肿瘤
肿瘤干细胞
转录抑制因子
Epithelial-mesenchymal transition
E-ca dherin
Gastrointestinal
Carcinoma
Cancer stem cell
Transcriptional repress or
