摘要
目的:观察伴院内感染早产儿血清C反应蛋白(CRP)水平的动态变化。方法:根据是否伴有院内感染将130例早产儿分为无院内感染的对照组105例和伴院内感染组25例,分别于出生后第1、3、5、7、9天采集早产儿足跟血,采用双抗体夹心法检测两组早产儿不同时间点的血清CRP水平动态变化。结果:伴院内感染组早产儿不同感染原因其血清CRP水平峰值相异,以皮肤感染最低,败血症最高,表现为皮肤感染<尿路感染<呼吸道感染<败血症。对照组早产儿血清CRP水平在监测期间未发生显著变化(P>0.05)。伴院内感染组早产儿出生后第1天血清CRP水平明显高于对照组(P<0.05),第3天升高达峰值,治疗后从出生后第5天逐渐下降,第7天仍高于对照组(P<0.05),至第9天接近对照组(P>0.05)。结论:动态监测血清CRP水平的变化对伴院内感染早产儿的临床防治具有较好的价值。
Objective：To observe the dynamic change of serum C-reactive protein（CRP） in premature infants with nosocomial infection.Methods：130 premature infants were divided into non-nosocomial infection group（105 premature infants） and nosocomial infection group（25 premature infants） according to combining with nosocomial infection or not,heel blood samples were obtained from the premature infants at 1,3,5,7,and 9 days after birth,double antibody sandwich method was used to detect the dynamic changes of serum CRP levels at different time points in the two groups.Results：The premature infants in nosocomial infection group with different causes of infection had different peaks of serum CRP levels,the premature infants with skin infection had the lowest peak level,the premature infants with sepsis had the highest peak level,showing a decreasing trend： skin infectionurinary tract infectionrespiratory tract infectionsepsis.The serum CRP levels of premature infants in non-nosocomial infection group didn＇t change significantly during the course of monitoring（P0.05）.On the first day after birth,the serum CRP level in nosocomial infection group was significantly higher than that in non-nosocomial infection group（P0.05）,the serum CRP level in nosocomial infection group peaked on the third day after birth,after treatment,it decreased gradually on the fifth day after birth,but it was still higher than that in non-nosocomial infection group on the seventh day after birth（P0.05）,while on the ninth day after birth,CRP levels in the two groups were nearly same（P0.05）.Conclusion：Monitoring serum CRP level dynamically has a good clinical value for clinical prevention and treatment of premature infants with nosocomial infection.
出处
《中国妇幼保健》
CAS
北大核心
2011年第33期5175-5177,共3页
Maternal and Child Health Care of China
关键词
早产儿
院内感染
C反应蛋白
动态变化
Premature infants
Nosocomial infection
C-reactive protein
Dynamic change
