摘要
以邻苯二酚与二甘醇二取代物为原料,氢氧化钾为碱和模板剂,在微波辅助下,采用"一锅煮"法合成二苯并-18-冠-6。经单因素及正交实验考察了原料、溶剂、时间、温度和功率对反应收率的影响,获得了最佳的工艺条件:以邻苯二酚与二氯乙醚为原料,二甲亚砜为溶剂,反应温度70℃,时间60 min,功率500 W,收率可达46.3%。
Dibenzo-18-crown-6 was synthesized from catechol and disubstituted diethylene glycol in one pot under microwave irradiation in the presence of potassium hydroxide as base and template reagent.The effects of the materials,solvent,microwave power,reaction time and temperature on the yield of the reaction were examined through single factor and orthogonal experiments.The optimal conditions were obtained as follows：catechol and 2,2′-dichloroethyl ether as raw materials,dimethyl sulfoxide as solvent,reaction temperature was 70 ℃,reaction time was 60 min,microwave power was 500 W,and the yield of dibenzo-18-crown-6 was 46.3%.
出处
《应用化学》
CAS
CSCD
北大核心
2011年第12期1453-1455,共3页
Chinese Journal of Applied Chemistry
基金
四川教育厅资助项目(2005C012)
