摘要
目的:探讨黄芩茎叶总黄酮(SSTF)预处理对脑缺血再灌注大鼠皮质神经元的保护作用。方法:线栓法建立大鼠局灶性脑缺血再灌注模型,Longa评分标准对各组大鼠进行神经功能缺损评分,透射电镜观察大鼠脑皮质神经元超微结构的变化。结果:SSTF预处理可明显降低缺血再灌注大鼠的神经功能缺损评分,改善脑皮质神经元的超微结构。结论:SSTF预处理对局灶性脑缺血再灌注大鼠皮质神经元具有一定的保护作用。
Objective：To investigate the protective effects of scutellaria baicalensis stem-leaf total flavonoid （SSTF） on cortical neurons of focal ischemia reperfusion rats.Methods：The focal ischemia reperfusion rats model was established by suture embolic method; Neurologic impairment was recorded according to Longa s standard; Ultrastructural changes of cortical neurons were observed by wansmission electron microscope.Results：SSTF pretreatment could decrease the neurologic impairment score significantly, improve the ultrastructure of cortical neurons obviously.Conclusions：SSTF pretreatment has certain protective effects on cortical neurons of focal ischemia reperfusion rats.
出处
《承德医学院学报》
2011年第4期360-361,共2页
Journal of Chengde Medical University
基金
河北省科技厅资助项目(07276101D-46)
河北省教育厅资助项目(2005227)
关键词
线栓法
局灶性脑缺血再灌注
超微结构
皮质神经元
Suture embolic method
Focal cerebral ischemia reperfusion
Ultrastructure
Cortical neuron
