摘要
目的观察短肽型营养制剂对重症急性胰腺炎患者肠道黏膜屏障功能的影响。方法将32例急性重症胰腺炎患者随机分为两组：治疗组（16例）、对照组（16例）。两组患者治疗过程中监测其血浆D-乳酸水平、尿乳果糖／甘露醇（L／M）值，观察重症胰腺炎患者ARDS、MODS发生率的情况。两组均给予常规治疗，治疗组在此基础上联合短肽型营养制剂（百普素）治疗，分别观察两组患者治疗后第7、14天D-乳酸水平、L／M值的变化。结果治疗第7、14天后，治疗组较对照组D-乳酸水平均明显降低（P〈0．05）；治疗14d后，较对照组尿L／M水平明显降低（P〈0．05）。治疗组ARDS及MODS发生率较对照组均有明显降低（P〈0．05）。结论短肽型营养制剂百普素能改善重症急性胰腺炎患者肠道黏膜屏障功能，降低肠道细菌、内毒素移位，并能降低重症急性胰腺炎患者ARDS、MODS的发生率。
Objective To observe the Effect of Peptisorb on the intestinal mucosal barrier function in patients with severe acute pancreatitis. Methods 32 cases of severe acute pancreatitis were randomized into the treatment group （ 16 cases）and the control group （ 16 cases）. During treatment, the plasma level of D- lactic acid,urinary lactulose/mannitol （L/M） values were determined. The ARDS and MODS incidence rate were determined with two group. Both groups were given to conventional treatment, Treatment group was added with Peptisorb besides conventional treatment; two groups of patients were observed D - lactate levels, L/M value changes after treated 7 d and 14 d. Results after treated 7 d and 14 d, compared with the control group, the D - lactate levels of treatment group were lower （P 〈0.05）; treatment after 14 d, the urinary L/M level of treatment group was lower than the control group （P 〈0.05）. after the end of treatment, ARDS and MODS incidence rate were lower （P 〈 0.05）. Conclusion Peptisorb has protective effects on the intestinal mucosal barrier function in severe acute pancreatitis patients. Peptisorb can reduce intestinal bacteria, endotoxin translocation, and ARDS and MODS incidence of severe acute pancreatitis.
出处
《中国急救医学》
CAS
CSCD
北大核心
2011年第12期1100-1102,共3页
Chinese Journal of Critical Care Medicine
