摘要
目的探讨中性粒细胞／淋巴细胞比值（NLR）是否可以作为胃癌患者的预后指标。方法回顾性分析1994—2006年间中山大学附属第一医院胃肠外科收治的经手术治疗的775例胃癌患者的临床资料，根据患者术前外周静脉血NLR大小分为低NLR组（NLR小于或等于3．79，652例）和高NLR组（NLR大于3．79，123例），比较两组患者的5年生存率：并进一步按TNM分期和手术方式进行分层分析。结果低NLR组和高NLR组胃癌患者5年生存率分别为44．0％和12．2％（P〈0．01）。TNMⅠ、Ⅱ、ⅢA、ⅢB及Ⅳ期病例中，低NLR组和高NLR组的5年生存率分别为97．8％和33．3％、55．4％和32．0％、30．2％和11．1％、15．5％和8．3％、10．7％和2．1％．差异均有统计学意义（均P〈0．01）。行D1、D2、D3、D4根治性手术及姑息性手术病例中，低NLR组和高NLR组的5年生存率分别为93．3％和33．3％、51．3％和20．4％、42．4％和10．5％、14.3％和2．0％、8．3％和2．2％。差异均有统计学意义（均P〈0．01）。结论NLR可以作为胃癌患者的预后因素，术前NLR大于3．79提示胃癌患者预后不良。
Objective To explore whether neutrophil-lymphocyte ratio （NLR） is an effective prognostic marker in gastric cancer. Methods Clinical data of 775 patients with gastric cancer in the First Affiliated Hospital of Sun Yat-sen University from 1994 to 2006 were analyzed retrospectively. According to preoperative NLR, the patients were divided into the low NLR group（NLR ≤ 3.79, n=652） and the high NLR group （NLR〉3.79, n=123）. The 5-year survival rates of two groups of different TNM stage, different surgical intervention were separately analyzed. Results The 5-year survival rates in the low NLR group and high NLR group were 44.0% and 12.2% respectively （P〈0.01）. In different TNM stages： stage Ⅰ （97.8% vs 33.3%）, stage Ⅱ （55.4% vs 32.0%）, stage Ⅲ A（30.2% vs 11.1%）, stage mB （15.5% vs 8.3%）, stage Ⅳ（10.7% vs 2.1%）, and in different surgical intervention： D1 curative gastrectomy （93.3% 33.3%）, D2 group （51.3% vs 20.4%）, D3 group （42.4% vs 10.5%）, D4 group （14.3% vs 2.0%）, and in palliative operation group（8.3% vs 2.2%）. There were significant differences of 5-year survival rate in TNM staging and surgical procedures between the high and low NLR groups （all P〈0.05）. Conclusion Preoperative NLR may be a prognostic marker in patients with gastric cancer.
出处
《中华胃肠外科杂志》
CAS
北大核心
2011年第12期944-947,共4页
Chinese Journal of Gastrointestinal Surgery
