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Aurora-A与survivin在甲状腺癌中的表达及意义 被引量：4

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摘要 目的:检测甲状腺癌组织中Aurora-A和survivin的表达,探讨Aurora-A和survivin在甲状腺癌发生中的作用及相关机制。方法:采用免疫组织化学SP法检测42例甲状腺癌,23例甲状腺瘤和12例癌旁正常甲状腺中Aurora-A和survivin蛋白的表达情况。结果:Aurora-A和survivin在癌旁正常甲状腺中未见表达,在甲状腺癌中表达率分别为66.7%和78.6%,在甲状腺瘤中表达率为17.4%和39.1%,Aurora-A和survivin在甲状腺癌与甲状腺瘤中表达差异有显著性(χ2=14.984,P=0.001;χ2=11.049,P=0.004);甲状腺癌中Aurora-A和survivin的表达具有相关性(r=0.499,P=0.001)。结论:Aurora-A和survivin的异常表达与甲状腺癌发生密切相关。Aurora-A可能通过扩增中心体,survivin可能通过抑制癌细胞凋亡共同参与细胞癌变,survivin直接激活Aurora-A激酶活性尚需进一步证实。
作者 杨勇 杨宏新
机构地区 内蒙古自治区人民医院肿瘤外科 内蒙古医学院基础医学院细胞生物教研室
出处 《实用医学杂志》 CAS 北大核心 2011年第23期4241-4243,共3页 The Journal of Practical Medicine
关键词 甲状腺肿瘤 SURVIVIN AURORA-A
分类号 R736.1 [医药卫生—肿瘤]
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参考文献16

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二级参考文献55

共引文献52

同被引文献41

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实用医学杂志
2011年 第23期

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