期刊文献+

路志正祛湿化浊通心方对老年血脂代谢异常的干预作用研究 被引量:3

Clinical study on senile abnormal lipid metabolism intervened by LU Zhi-zheng’s dampness-removing, turbid-resolving and heart-communicating formula
原文传递
导出
摘要 目的 观察路志正教授祛湿化浊通心方干预老年血脂代谢异常的疗效及安全性。方法 采用随机数字表法将60例老年血脂代谢异常患者随机分为两组各30例,治疗组给予祛湿化浊通心方治疗,1剂/d,分2次温水冲服;对照组口服绞股蓝总苷片,60 mg/次,3次/d,餐前服用。两组患者均治疗4周为1个疗程,2个疗程后统计疗效。结果 治疗组治疗后除高密度脂蛋白(HDL-C)外,总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)均较治疗前明显改善[分别为(5.81±1.70)mmol/L、(3.05±2.30)mmol/L、(3.39±1.11)mmol/L,P<0.01或0.05],并低于对照组[分别为(6.16±1.91)mmol/L、(3.03±1.89)mmol/L、(3.81±0.63)mmol/L,P<0.01或0.05]。治疗组LDL-C达标情况,以及对胸闷、头昏、头重如裹、头痛、口黏不渴、大便不爽、恶心呕吐、肢体沉重等中医证候疗效优于对照组(平均秩分别为23.83、38.10、36.10、34.70、36.77、39.82、33.38、34.17);治疗组在血、尿、便常规、心电图、ALT、AST、Cr等安全性指标方面未见异常。结论 祛湿化浊通心方可明显改善血脂代谢异常患者的临床症状及体征,有效调节血脂异常,疗效优于绞股蓝总苷片。 Objective To observe the effect and safety of treating senile abnormal lipid metabolism with LU Zhi-zheng’s dampness-removing, turbid-resolving and heart-communicating formula. Methods 60 patients were randomly divided into a treatment, treated with LU’s formula, one dosage per day, and a control group, treated with gypenosides, 60mg/tablet, three times per day, with 30 patients in each group. Both groups were treated two therapeutic courses, which were 8 weeks. Results Except HDL-C, other indexes including TC, TG, LDL-C in the treatment group were all obviously improved after the treatment [the statistical values were(5.81±1.70)mmol/L,(3.05±2.30)mmol/L,(3.39±1.11)mmol/L respectively,P〈0.01 or 0.05], which were also better than the control group[the statistical values were(6.16±1.91)mmol/L,(3.03±1.89)mmol/L,(3.81±0.63)mmol/L,P〈0.01 or 0.05]. Symptoms improvement such as chest oppression, dizziness, heaviness of head, headache, sticky mouth without thirsty, constipation, nausea and vomiting, and heaviness of limbs in the treatment group were also better than the control group, with mean rank were 23.83、38.10、36.10、34.70、36.77、39.82、33.38、34.17 respectively. No abnormal changes were found in indexes of blood routine, urinary routine, stool routine, ECG, ALT, AST and Cr. Conclusion LU Zhi-zheng’s dampness-removing, turbid-resolving and heart-communicating formula improved clinical symptoms and signs of abnormal lipid metabolism patients, its therapeutic effects were better than gypenosides.
出处 《国际中医中药杂志》 2011年第12期1064-1068,共5页 International Journal of Traditional Chinese Medicine
关键词 血脂代谢异常 祛湿化浊通心方 Abnormal metabolism of lipid Dampness-removing turbid-resolving and heart-communicating formula
  • 相关文献

参考文献4

二级参考文献13

共引文献148

同被引文献49

引证文献3

二级引证文献23

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部