银杏叶提取物对慢性阻塞性肺疾病急性加重期患者白细胞介素-8和肿瘤坏死因子-α的影响被引量：7

Efect of Ginkgo Biloba Extract on the expression of Interleukin-8 and tumor necrosis factor-α in acute exacerbations of chronic obstructive pulmonary disease patients

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摘要目的观察银杏叶提取物治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者白细胞介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)的影响。方法 AECOPD患者96例随机分为治疗组(50例)和对照组(46例),对照组给予常规对症治疗(吸氧、化痰、平喘、抗感染等),治疗组在常规治疗基础上加用银杏叶提取物制剂(金纳多注射液)20 mL加入0.9%氯化钠注射液250 mL静滴,1次/d,疗程14 d。观察两组患者症状体征、血气分析及肺功能指标的变化,同时检测两组患者血清IL-8和TNF-α水平的变化。结果治疗组总有效率优于对照组(P<0.05);治疗组血清中IL-8和TNF-α浓度较对照组下降,差异有统计学意义(P<0.05或0.01)。结论银杏叶提取物可降低AE-COPD血清中IL-8和TNF-α浓度,抑制炎症细胞生成,对AECOPD气道炎症具有明显的抑制作用。

作者刘忠刘馨许国岩

机构地区辽宁医学院附属第一医院辽宁陆军预备役高炮一师三团卫生队

出处《中国生化药物杂志》 CAS CSCD 北大核心 2011年第6期482-484,共3页 Chinese Journal of Biochemical Pharmaceutics

关键词银杏叶提取物慢性阻塞性肺疾病白细胞介素-8 肿瘤坏死因子-Α

分类号 R974 [医药卫生—药品]

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