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Association of Expression of Leucine-rich Repeats and Immunoglobulin-like Domains 2 Gene with Invasiveness of Pituitary Adenoma 被引量：7

Association of Expression of Leucine-rich Repeats and Immunoglobulin-like Domains 2 Gene with Invasiveness of Pituitary Adenoma
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摘要 The Leucine-rich repeats and immunoglobulin-like domains-2（LRIG2） gene expression in pituitary adenoma and its correlation with tumor invasiveness were studied.The expression of LRIG2 mRNA and protein in human pituitary adenoma obtained surgically was detected by RT-PCR（39 cases） and immunohistochemical staining（30 cases）.It was found that LRIG2 was mostly localized at the nucleus of the pituitary adenoma cells.Its expression was significantly higher in the invasive cases than in the non-invasive cases.LRIG2 protein was positive in 14 cases out of 21 cases of invasive adenoma,but only 2 cases were positive in 9 cases of non-invasive adenoma.The positive expression rate of LRIG2 mRNA was 91.3% in invasive cases（total 23 cases） and 62.5% in non-invasive cases（total 16 cases）,respectively.LRIG2 gene is overexpressed in invasive pituitary adenoma.It may play an important role in pituitary adenoma invasiveness and further studies are necessary to elucidate the mechanism under this phenomenon. The Leucine-rich repeats and immunoglobulin-like domains-2（LRIG2） gene expression in pituitary adenoma and its correlation with tumor invasiveness were studied.The expression of LRIG2 mRNA and protein in human pituitary adenoma obtained surgically was detected by RT-PCR（39 cases） and immunohistochemical staining（30 cases）.It was found that LRIG2 was mostly localized at the nucleus of the pituitary adenoma cells.Its expression was significantly higher in the invasive cases than in the non-invasive cases.LRIG2 protein was positive in 14 cases out of 21 cases of invasive adenoma,but only 2 cases were positive in 9 cases of non-invasive adenoma.The positive expression rate of LRIG2 mRNA was 91.3% in invasive cases（total 23 cases） and 62.5% in non-invasive cases（total 16 cases）,respectively.LRIG2 gene is overexpressed in invasive pituitary adenoma.It may play an important role in pituitary adenoma invasiveness and further studies are necessary to elucidate the mechanism under this phenomenon.
作者 张华楸 颜青 许书添 欧一波 叶飞 王宝峰 雷霆 郭东升
机构地区 Department of Neurosurgery
出处 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2011年第4期520-523,共4页 华中科技大学学报（医学英德文版）
关键词 LRIG2 pituitary adenoma INVASIVENESS LRIG2 pituitary adenoma invasiveness
分类号 R736.4 [医药卫生—肿瘤]
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参考文献26

  • 1郭东生,韩林,舒凯,陈坚,雷霆.Down-regulation of Leucine-rich Repeats and Immunoglobulin-like Domain Proteins (LRIG1-3) in HP75 Pituitary Adenoma Cell Line[J].Journal of Huazhong University of Science and Technology(Medical Sciences),2007,27(1):91-94. 被引量：11
  • 2Dongsheng Guo,Lin Han,Kai Shu,Jian Chen,Ting Lei.Down-regulation of leucine-rich repeats and immunoglobulin-like domain proteins (LRIG1-3) in HP75 pituitary adenoma cell line[J]. Journal of Huazhong University of Science and Technology . 2007 (1)
  • 3Dongsheng Guo,Jonas Nilsson,Hannu Haapasalo,Olayinka Raheem,Tommy Bergenheim,H?kan Hedman,Roger Henriksson.Perinuclear leucine-rich repeats and immunoglobulin-like domain proteins (LRIG1-3) as prognostic indicators in astrocytic tumors[J]. Acta Neuropathologica . 2006 (3)
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二级参考文献11

  • 1Dongsheng Guo,Jonas Nilsson,Hannu Haapasalo,Olayinka Raheem,Tommy Bergenheim,H?kan Hedman,Roger Henriksson.Perinuclear leucine-rich repeats and immunoglobulin-like domain proteins (LRIG1-3) as prognostic indicators in astrocytic tumors[J].Acta Neuropathologica.2006(3)
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  • 7Guo D,Holmlund C,Henriksson R et al.The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea[].Genomics.2004
  • 8Holmlund C,Nilsson J,Guo D et al.Characterization and tissue-specific expression of human LRIG2[].Gene.2004
  • 9Nilsson J,Vallbo C,Guo D et al.Cloning, characteriza- tion, and expression of human LIG1[].Biochemical and Biophysical Research Communications.2001
  • 10Suzuki Y,Miura H,Tanemura A et al.Targeted disrup- tion of LIG-1 gene results in psoriasiform epidermal hy- perplasia[].FEBS Letters.2002

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二级引证文献13

Journal of Huazhong University of Science and Technology(Medical Sciences)
2011年 第4期

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