摘要
目的 探索抗核周因子（ＡＰＦ） 、抗角蛋白抗体（ＡＫＡ）、抗Ｓａ 抗体及抗ＲＡ３３／３６ 抗体检测对ＲＡ的早期诊断价值。方法 对未肯定诊断的关节痛／ 关节炎病人１１６ 例进行上述四种抗体检测并随访观察。ＡＰＦ和ＡＫＡ用间接免疫荧光法进行检测。抗Ｓａ 抗体和抗ＲＡ３３／３６ 抗体用免疫印迹法检测。结果 对１１６ 例未肯定诊断的关节痛／ 关节炎患者随访４ ～１８ 个月。ＡＰＦ阳性的２９ 例中，最后确诊为ＲＡ２０ 例（６９ ％ ）；ＡＫＡ３０ 例中确诊ＲＡ１６ 例（５３－３ ％ ）；抗Ｓａ 抗体３９ 例中确诊ＲＡ１９例（４８－７ ％） 。而ＡＰＦ、ＡＫＡ和抗Ｓａ 抗体阴性组中，追随后确定为ＲＡ 者比例不高，而发展为肯定非ＲＡ的患者明显高于阳性组，两组比较差异有显著性（ Ｐ＜ ０－０５）。结论 四种自身抗体均可出现在ＲＡ 确诊前的病人中，任何两种以上自身抗体阳性对ＲＡ 诊断早期有较高的价值。
Objective To explore the diagnostic value of antiperinuclear factor (APF),antikeratin antibody (AKA),anti Sa antibody and anti RA33/36 antibody in early RA patients.Methods One hundred and sixteen unclassified arthralgia/arthritis patients were studied and followed up for 4 to 8 months.APF and AKA were detected by indirect immunofluorescence,anti Sa and anti RA33/36 antibodies were detected by immunoblotting.Results At the end of follow up,20(69%) out of 29 APF positive patients were diagnosed to have RA,16(53 3%) out of 30 AKA positive and 19(48 7%) out of 39 anti Sa positive patients were also diagnosed to have RA.The rates of APF,AKA and anti Sa negative patients diagnosed to have RA were significantly lower than those of serum positive patients.Conclusion The 4 kinds of autoantibodies can be detected in early RA patients and have high value on early diagnosis of RA.
出处
《中华风湿病学杂志》
CAS
CSCD
1999年第4期208-211,共4页
Chinese Journal of Rheumatology
基金
卫生部重点学科基金!(97010205)
关键词
类风湿性关节炎
血清诊断
APF
AKA
Arthritis,rheumatoid Antiperinuclear factor Antikeratin antibody Anti RA33 antibody Anti Sa antibody
