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桂西地区壮族人群肾素—血管紧张素系统基因多态性分析 被引量：2

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摘要 目的探讨肾素—血管紧张素系统(RAS)中血管紧张素Ⅱ1型受体(AT1R)基因A1166C多态、血管紧张素Ⅰ转化酶(ACE)基因插入/缺失(I/D)多态及血管紧张素原(AGT)基因M235T多态在桂西地区壮族人群中的分布频率,比较其在不同种族间分布的差异。方法采用PCR-RFLP技术和DNA测序法检测150例壮族人AT1R基因A1166C、ACE基因I/D和AGT基因M235T多态性,结合文献进行不同种族间的比较分析。结果桂西地区壮族人群AT1R基因A1166C基因型和等位基因频率与土耳其比较差异有统计学意义;桂西地区壮族人群ACE基因I/D基因型频率与法国人、土耳其人比较差异有统计学意义,基因型和等位基因频率与黎巴嫩人、巴林人比较差异有统计学意义;桂西地区壮族人群AGT基因M235T基因型和等位基因频率与法国人、蒙古族人、土耳其人、波兰人比较有统计学差异(P均<0.01)。结论 RAS基因多态性在不同种族间分布频率存在差异,这种差异势必会影响RAS基因在一些疾病特别是地方高发性疾病发生、发展中的作用。
作者 尤燕舞 黄海玲 林栩
机构地区 右江民族医学院附属医院 右江民族医学院组胚教研室
出处 《山东医药》 CAS 北大核心 2011年第41期43-45,共3页 Shandong Medical Journal
基金 广西科学基金资助项目(桂科青0542074) 广西教育厅资助项目(201012MS180)
关键词 血管紧张素Ⅱ1型受体 血管紧张素1转化酶 血管紧张素原 基因多态性 种族
分类号 Q754 [生物学—分子生物学]
  • 相关文献

参考文献9

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二级参考文献21

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共引文献10

同被引文献20

  • 1石光清,向谷良,戴中伟,邱娟,郭肖南.血浆肾素、血管紧张素II、醛固酮含量在原发性高血压病患者治疗前后的临床意义[J].实用预防医学,2005,12(6):1297-1298. 被引量：4
  • 2孟群,沈颖,江载芳.原发性肾病综合征患儿血管紧张素原和血管紧张素转换酶基因多态性的检测与临床分析[J].中国实用儿科杂志,2007,22(6):420-423. 被引量：8
  • 3Kothari S T, Chheda P, Chatteriee L, et al. Molecular analysisof genetic variation in angiotensin I-converting enzymeidentifies no association with sporting ability: First reportfrom Indian population[J]. Indian J Hum Genet, 2012,18(1):62-65.
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  • 10巫桂寿,刘小燕,陈佩玲,欧阳志斌.原发性高血压6个相关基因的研究[J].中华全科医学,2009,7(7):670-671. 被引量：2

引证文献2

二级引证文献4

山东医药
2011年 第41期

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