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习惯性流产夫妇外周血淋巴细胞R显带法染色体核型分析 被引量:4

Chromosomal karyotype analysis of peripheral blood lymphocyte using R-band method in couples with spontaneous abortion
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摘要 目的探讨习惯性流产与染色体异常的关系。方法用RPMI1640培养基,采用微量全血培养法,对129对习惯性流产夫妇外周血淋巴细胞染色体进行了分析。结果 258例习惯性流产中,检出异常核型12例,占受检人数的4.6%,其中男性5例,女性7例,这些异常核型中,7例为染色体平衡易位,2例为超二倍体(47,XYY 1例;47,XXX 1例),3例为变异核型(1例Yp+,1例Yq-和1例2q+)。结论习惯性流产与染色体异常有关。习惯性流产夫妇外周血淋巴细胞染色体异常率为4.6%,其中平衡异位是引起习惯性流产的主要染色体核型。 Aim To explore the relationship between spontaneous abortion and chromosomal abnormalities.Method Using the method of small volume blood culture in RPMI1640,the chromosome of circular lymphocytes in 129 couples with spontaneous abortion was detected.Results 12 cases with abnormal chromosome were found among 258 cases,accounted 4.6 %,of all,females were 7 cases and males were 5 cases.Among these chromosomal abnormalities,7 cases belonged to the balanced translocation of chromosome and 2 cases were hyperdiploid(1 case,47,XYY;1 case,47,XXX),3 cases heterokaryotype included Yp+,Yq-and 2q+1.Conclusions The spontaneous abortion is associated with chromosomal abnormalities.The rate of the abnormalities chromosome of circular lymphocytes in the couples with spontaneous abortion were 4.6 %.Balance translocation is a common chromosomal karyotype in spontaneous abortion couples.
作者 巫梅
出处 《安徽医药》 CAS 2011年第12期1543-1544,共2页 Anhui Medical and Pharmaceutical Journal
关键词 习惯性流产 遗传学 染色体异常 spontaneous abortion/genetics chromosomal abnormalities
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