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脂必妥胶囊治疗高脂血症多中心临床试验 被引量:22

Zhibituo Capsules in treatment of hyperlipidemia: a multicenter clinical trial
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摘要 目的:验证脂必妥胶囊治疗高脂血症的疗效和安全性。方法:采用随机、对照、多中心研究方法。脂必妥胶囊治疗组300 例,男性156 例,女性144例,年龄58 a±s8 a; 血脂康对照组150 例;男性71例,女性79 例,年龄57 a ±8 a 。脂必妥胶囊:1 粒,po,bid; 血脂康胶囊:2 粒,po,bid。疗程均为8wk 。结果:脂必妥组临床控制116 例,显效113 例,有效41 例,显效率为76 .3 % , 总有效率为90 .0 % ;血脂康组临床控制45 例,显效66 例,有效17 例,显效率74 .0 % ,总有效率85 .3 % ( P< 0 .05) 。未发现明显不良反应。结论:脂必妥胶囊对高脂血症安全有效。 AIM: To evaluate the efficacy and safety of Zhibituo in treating hyperlipidemia. METHODS: In randomized, comparative and multicenter studies, Zhibituo therapy group of 300 patients (M 156, F 144, age 58 a±s 8 a) received Zhibituo 1 capsule, po, each time in the morning and evening for 8 wk; Xuezhikang control group of 150 patients (M 71, F 79, age 57 a±8 a) received Xuezhikang 2 capsules, po, each time in the morning and evening for 8 wk. RESULTE: Zhibituo group total effective rates were 90.0%. Xuezhikang group total effective rates were 85.3% (P<0.05). There were no severe adverse reactions. CONCLUSION: Zhibituo is a safe and effective antihyperlipidemia drug. among three groups,but there was no significant differences between mixed gas groups and air group.Airway reactivity to histamine was remarkably increased after inhaling mixed gas.Percentage of neutrophil in BAL increased.Conclusion:Airway hyperresponsiveness can be induced by short time inhaling SO 2 and NO 2 mixed gas in Guinea pigs. Key words:Sulfur Dioxide; Nitrogen Dioxide; Airway responsiveness; Guinea pig
出处 《中国新药与临床杂志》 CAS CSCD 北大核心 1999年第6期365-367,共3页 Chinese Journal of New Drugs and Clinical Remedies
关键词 脂必妥 高脂血症 多中心研究 治疗 Zhibituo hyperlipidemia multicenter studies
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参考文献4

  • 1胡婉英,董跃荣,张健元,唐继业.脂必妥治疗高脂血症的疗效[J].新药与临床,1997,16(1):52-54. 被引量:11
  • 2徐济民 陈曙霞 等.脂必妥与安慰剂高脂血症的随机双盲多中心研究[J].新药与临床,1997,16:47-51.
  • 3胡婉英,新药与临床,1997年,16卷,52页
  • 4徐济民,新药与临床,1997年,16卷,47页

二级参考文献2

  • 1徐传隆,中药辞海.1,1993年,2384页
  • 2胡随瑜,实用中西医结合杂志,1991年,4卷,740页

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