摘要
目的：研究不同浓度补骨脂中补骨脂素和异补骨脂素的鼻粘膜吸收规律。方法：建立大鼠鼻腔重循环模型，用ＨＰＬＣ 法测定循环液中补骨脂素和异补骨脂素的含量变化。结果：补骨脂中补骨脂素和异补骨脂素在鼻粘膜的吸收符合零级动力学特征，随着药液浓度的增加，补骨脂素和异补骨脂素的吸收存在饱和现象。结论：在开发补骨脂鼻腔给药制剂时，要控制恰当的浓度。
Objective:To investigate the nasal absorption regularities of psoralen and isopsoralen of different concentrations.Method:Building an experimental model of rat in situ nasal recirculation and determining the contents of psoralen and isopsoralen by HPLC.Result:The nasal absorption of psoralen and isopsoralen fitted in with zero order kinetics,getting saturated with the increase of concentration.Conclusion:A suitable concentration is necessary for the preparation of nasal remedies psoralen and isopsoralen.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1999年第11期689-691,共3页
China Journal of Chinese Materia Medica
基金
广东省科委重点科技攻关资助
关键词
补骨脂素
异补骨脂素
鼻腔吸收
HPLC
psoralen
isopsoralen
in situ nasal recirculation method
nasal absorption (original article on page 689)
