摘要
目的:探讨血清SCCAg及CA125用于宫颈鳞癌诊断、手术治疗及预后的价值。方法:选取ⅠA2～ⅡA期宫颈鳞状细胞癌为研究组,20例CIN及20例慢性宫颈炎分别为对照组1和对照组2。采用固相夹心法酶联免疫吸附实验(ELISA)检测血清SCCAg的数值,采用化学发光免疫分析法(CLIA)检测血清CA125数值。比较分析血清SCCAg及CA125与宫颈鳞癌临床病理特征、手术疗效及预后的关系。结果:宫颈鳞癌组术前血清SCCAg及CA125水平均高于慢性宫颈炎组,差异均具有统计学意义(P<0.01)。宫颈鳞癌组术前SCCAg水平高于CIN组,差异有统计学意义(P<0.001);宫颈鳞癌组术前CA125水平与CIN组的差异无统计学意义(P=0.049,P>0.0167)。血清SCCAg、CA125诊断宫颈鳞癌的临界值分别为1.03ng/ml、8.16U/ml。血清SCCAg、CA125及两项联合诊断宫颈癌的ROC曲线下面积分别为0.954、0.718、0.960,两项联合后诊断性能无明显增加。宫颈鳞癌术前血清SCCAg随临床分期增加具有线性增加的趋势。脉管有否癌栓、盆腔淋巴结有否转移也与术前血清SCCA水平有关,差异有统计学意义(P=0.011,P=0.043)。宫颈鳞癌组手术治疗后的血清SCCAg及CA125水平均有逐渐降低趋势,差异有统计学意义(P均<0.001)。结论:血清SCCAg对宫颈鳞癌有较高的诊断价值,可考虑作为诊断及手术疗效评估指标之一,有助于初步判断脉管及盆腔淋巴结转移。血清CA125对于宫颈鳞癌诊断、手术评估及随访的价值均低于SCCAg,与SCCAg联合不能增加诊断的敏感度和特异度。
Objective：To investigate the clinical values of serum SCCAg and CA125 in the evaluation of diagnosis and prognosis in cervical squamous carcinoma（CSCC）.Methods：SCCAg and CA125 were detected by the methods of ELISA and CLIA respectively.The control group was divided into two subgroups,CIN group and chronic cervicitis group both with 20 cases.The observed group consist of 30 patients with CSCC of stageⅠA2~ⅡA.SCCAg and CA125 were detected in observed group pre-and post-operation.The correlation of SCCAg and CA125 with the pathological features as well as the clinic outcomings of CSCC patients were analyzed.Results：Increased serum level of SCCAg and CA125 were observed in CSCC group pre-operation,the difference was significant when compared with those in chronic cervicitis group（P0.001）.The values of SCCAg in CSCC group was higher than those in CIN group,the difference was significant（P0.001）,but no significant difference was observed about the serum values of CA125 between two groups（P=0.049,P0.0167）.The threshold of the serum value of SCCAg and CA125 for diagnosis CSCC was 1.03ng/ml and 8.16U/ml respectively pre-operation.The areas of SCCAg and CA125 under the ROC curve（AUC）were 0.954 and 0.718 respectively.The AUC of SCCAg combined with CA125 was 0.960,thus,no improved diagnostic value was observed by combination of SCCAg and CA125.The serum values of SCCAg was positively linear associated with the clinical stage,and highly correlated to the cancer lympho-vascular space invision and lymphonodus metastasization（P=0.011,P=0.043）.Conclusions：SCCAg can be useful for the diagnosis and evaluation the effectiveness of operation and prognosis in CSCC patients,as well as LVSI and pelvic lymphonodus metastasis.The evaluating values of CA125 both in diagnosis and prognosis of CSCC are lower than that of SCCAg.Combination SCCAg with CA125 can not improve the sensitivity and specificity of diagnosis in CSCC patients.
出处
《现代妇产科进展》
CSCD
北大核心
2011年第11期873-876,共4页
Progress in Obstetrics and Gynecology
基金
贵州省科技厅基金课题[No:黔科合J字(2008)2197]
关键词
鳞状细胞癌抗原
癌抗原125
宫颈鳞癌
诊断
手术
预后
Squamous cell carcinoma antigen
Cancer antigen 125
Cervical squamous carcinoma
Diagnosis
Surgical treatment
Prognosis
