摘要
目的:探讨博宁对恶性肿瘤骨转移的治疗作用及骨骼修复作用。方法:35 例患者接受博宁单独或联合化疗治疗。结果:骨痛总缓解率为80 .0% ,单用博宁及博宁联合化疗两组之间无明显差异,有效率分别为76 .5% 和86 .3 % ,疼痛缓解与病种之间也未发现明显差别, 博宁应用后疼痛缓解的显效时间为2～15 天, 平均为4 天左右,28 例患者疼痛缓解后有11 例患者再次出现疼痛复发,时间为用药后1 ～4 个月,平均3 个月,治疗后血清离子钙水平明显降低。本组患者随访3 个月～2 年,骨折发生率仅为11 .4% ,有3 例患者肿瘤骨转移部位的骨质有修复现象。结论:博宁对于恶性肿瘤骨转移所引起骨痛和高血钙具有较好的治疗作用,长期应用会出现骨骼修复,减少骨并发症的发生。
Purpose: To evaluate therapeutic effect of Bonin in patients with cancer and bone metastases. Methods: Seventeen patients received only Bonin, 18 patients with addition of combination chemotherapy. Results: Response rate of bone pain relief were seen in 76.5% of patients in Bonin alone group and 86.3% in Bonin plus chemotherapy group. Serum calcium after treatment declined. The incidence of complication of bone fracture was 11.4% (4/35), 3 patients were found with improvement of bone mineral density on X-rays. Conclusion: Bonin can relieve bone pain and improve bone mineral density and protect against skeletal complications in patients with cancer and lytic bone metastases.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1999年第11期847-850,共4页
Chinese Journal of Clinical Oncology
关键词
恶性肿瘤
骨转移
博宁
治疗
Cancer Bone metastases Bonin Therapy
