摘要
目的:为了探讨2型糖尿病(DM2)患者血脂、尿酸(SUA)和C-反应蛋白(CRP)测定的临床意义。方法:采用生化法测定了78例DM2患者和66例正常对照组的血脂(TC、TG、HDL-C和LDL-C)水平,过氧化物酶免疫分析测定了SUA水平以及免疫比浊法测定了CRP水平,并与66例正常对照组进行了对比性分析。结果:78例DM2患者的TC、TG和LDL-C水平较之66例正常对照组明显增加(P<0.05～<0.01),血清HDL-C水平明显降低(P<0.01),尤以血清TG水平的增高和HDL-C水平的降低最为突出。36例DM2患者治疗明显好转后,血清TC和LDL-C恢复正常,TG水平明显降低(P<0.05),HDL-C水平明显增高(P<0.05),78例DM2患者的SUA和CRP水平较之66例正常对照组明显增高(P均<0.01),36例DM2患者治疗明显好转后,SUA和CRP水平明显降低(P均<0.05)。结论:DM2患者不仅存在着血脂和尿酸代谢紊乱,而且也是一种低度炎症反应性疾病。血脂、SUA和CRP水平的动态观察是考核疗效有价值的指标。
Objective To expore the clinical significance of determining blood lipid.serum uric acid（SUA） and C-reactive protein（CRP） levels in patients with type 2 diabetes mellitus（DM2）.Methods Blood lipid（with biochemistry）,SUA（with peroxide enzyme immunoassay） and serum CRP（with immunoturbidimetry） levels were determined in 78 patients with DM2 and 66 normal controls and done comparative analysis.Results In blood lipid analysis,serum TC,TG and LDL-C levels were significantly higher in 78 patients with DM2 than those in 66 controls（P0.05~0.01）,but serum HDL-C level was low（P0.01）before therapy.Serum TG levels increase and HDL-C levels decrease especially.After therapy,serum TC and LDL-C return to normal levels,serum TG was obviously low,but serum HDL-C level was notably increase.The SUA and serum CRP levels were significantly higher in 78 patients with DM2 than those in 66 controls（P all 0.01）.After therapy,the SUA and serum CRP levels were remarkably low.Conclusion As in DM2,there existed blood lipid and uric acid metabolic disorder and manifested lower inflammatory reactive disease.The blood lipid,serum SUA and CRP levels dynamic analysis might be used as an useful indicator to reflect the therapeutic effect.
出处
《放射免疫学杂志》
CAS
2011年第6期684-686,共3页
Journal of Radioimmanology
