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不稳定型心绞痛患者血浆超敏C反应蛋白和单核细胞趋化蛋白-1的变化及临床意义 被引量：5

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摘要 目的探讨血浆超敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)和单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)水平在不稳定型心绞痛(unstable angina,UA)患者中的变化及临床意义。方法按Braunwald标准,将115例心功能正常的UA患者分为ⅠB组(35例)、ⅡB组(40例)及ⅢB组(40例),并选30例稳定型心绞痛患者作为对照组。入院后24 h内留取血标本待测hs-CRP和MCP-1;随访观察出院后90 d内主要不良心血管事件(major adverse cardiovascular events,MACE)。结果 (1)UA各组hs-CRP和MCP-1均显著高于对照组(P<0.05),ⅢB组显著高于ⅠB组和ⅡB组(P<0.05)。(2)ⅢB组90 d内MACE发生率显著高于ⅠB组和ⅡB组(P<0.05),ⅡB组MACE发生率与ⅠB组比较,差异无统计学意义(P>0.05)。(3)90 d内有MACE组hs-CRP和MCP-1与无MACE组比较,差异均有统计学意义(P<0.05)。结论血浆hs-CRP和MCP-1水平对于UA患者病情严重程度与近期不良预后的评估具有一定的价值。
作者 彭杰成 严卫国
机构地区 安徽省安庆市第一人民医院心内科
出处 《广东医学》 CAS CSCD 北大核心 2011年第24期3243-3245,共3页 Guangdong Medical Journal
关键词 超敏C反应蛋白 单核细胞趋化蛋白-1 不稳定型心绞痛 预后
分类号 R587.2 [医药卫生—内分泌]
  • 相关文献

参考文献11

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共引文献30

同被引文献37

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二级引证文献20

广东医学
2011年 第24期

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