摘要
目的:探讨不同剂量利培酮对女性精神分裂症患者血脂的影响,评价药物的安全性。方法:予以利培酮治疗的113例女性精神分裂症患者,按使用利培酮剂量不同分为两组:低剂量组(≤3 mg/日)和高剂量组(>3 mg/日),分别于治疗前、治疗第4周、第8周检测患者血清胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)的水平。结果:不同剂量利培酮可引起女性精神分裂症患者血脂TC、TG升高,且呈剂量相关性。结论:利培酮可引起血脂异常,与剂量相关,在治疗女性精神分裂症时应采取相应的干预措施。
Objective：To observe the serum lipid levels in Risperidone treatment of different dosage in female schizophrenics and evaluate drug safety. Methods： 113 female schizophrenics in Risperidone treatment were divided into the low - dose group （ ≤ 3mg/d） and the high- dose group （ 〉 3mg/d）. The serum lipid levels were detected before treatment and 4,8 weeks after treatment. Results： The serum cholesterol I （ TC ） and triglycerides （TG） levels of the high - dose group were significantly higher than those of the low- dose group in female schizophrenics. Conclusions： Risperidone can cause serum lipid rise, and there is positive relationship between the serum TC and TG levels and the doses of Risperidone. Appropriate intervention measures should be taken in the treatment of female schizophrenics.
出处
《中国民康医学》
2011年第23期2898-2899,共2页
Medical Journal of Chinese People’s Health
关键词
利培酮
剂量
精神分裂症
血脂
女性
Risperidone
Dosage
Schizophrenia
Serum lipid
Female
