摘要
目的：介绍ＨＭＧＣｏＡ 还原酶抑制剂类药的研究进展，为临床合理用药提供参考。方法：以国内外发表的论文为基础，经分析，归纳，从药理作用、体内过程、临床应用、副作用及产品发展概况等方面介绍洛伐他汀、普伐他汀、辛伐他汀、氟伐他汀及西伐他汀等药品。结果与结论：大量资料表明，ＨＭＧＣｏＡ 还原酶抑制剂是一类疗效显著、毒副作用少，耐受性好的理想降血脂药物，该类药的问世为治疗高胆固醇血症开辟了新途径。
OBJECTIVE:To introduce the advancement of HMG CoA reductase inhibitors and provide references for the safe and effective application of these medicines in clinical treatment.METHOD:According to articles published,mechanisums,pharmacokinetics,pharmacodynamics,clinical uses and products development of lovastatin,provastatin,simvastatin,fluvastatin,and cerivastatin were reviewed.RESULTS and CONCLUSION:From these information it is suggested that HMG CoA RI is a kind of safe,effective and tolerable lipid modulators.
出处
《中国现代应用药学》
CAS
CSCD
1999年第6期1-4,共4页
Chinese Journal of Modern Applied Pharmacy
