摘要
目的:探讨高效抗逆转录病毒治疗(HAART)对HIV感染者唾液中人类疱疹病毒5至8型即CMV、HHV-6、HHV-7和HHV-8的分布影响情况。方法:利用巢式PCR技术对受试人群唾液CMV、HHV-6、HHV-7和HHV-8 DNA的存在进行检测,并采用SPSS 18.0软件建立数据库并进行相关指标的统计分析。结果:HIV患者HAART组与非HAART组比较,4种HHV唾液检出率并无差异(P>0.05),HAART组、非HAART组与正常组比较有差异性,而且三组都存在CMV、HHV-6、HHV-7和HHV-8多重感染,HIV人群病毒共同检出率高于正常组,非HAART组高于其它两组。结论:HIV患者中口腔疱疹病毒5-8型感染较为普遍,其中以HHV-6和HHV-7最为突出,HHV-8最低,唾液可能在疱疹病毒传播中起作用。
Objective： This study aimed to determine the presence of CMV, HHV-6, HHV-7 and HHV-8 and HHV-8 in the saliva of HIV-seropositive patients with HAART and non-HAART. Method： CMV, HHV-6, HHV-7 and HHV-8 DNA of Unstimulated whole saliva from 245 HIV-infected patients and 30 healthy HIV-seronegative controls were analyzed by nested- PCR assays. The data was analyzed by the use of SPSS Statistical software version 18.0. Result：There was no difference of detection rates of these four HHVs in saliva between HIV patients with HAART group and non-HAART group （P 〉0.05）.HAART group, non-HAART group compared with the normal group differences, and the three groups are present CMV, HHV-6, HHV-7 and HHV-8 multiple infections. Conclusion： Oral herpesvirus infection in patients with HIV infection is very common, of which the most prominent are HHV-6 and HHV-7. Saliva may play a possible role in HHVs spread.
出处
《临床口腔医学杂志》
2011年第12期724-726,共3页
Journal of Clinical Stomatology
基金
国家自然科学基金资助项目(30860315
81160135)
云南省应用基础研究资助项目(2008ZC146M)
