摘要
目的了解血液科住院患者医院感染临床分离菌的分布及耐药性,指导临床经验性用药。方法对医院血液科2007年1月-2010年12月住院患者临床分离的病原菌分布及耐药性进行分析。结果分离到455株病原菌,以革兰阴性菌为主,革兰阳性菌感染呈逐渐下降趋势;大肠埃希菌为主要病原菌,大肠埃希菌和肺炎克雷伯菌产超广谱β-内酰胺酶的检出率分别为61.1%和38.3%,肠杆菌科细菌对碳青霉烯类和β-内酰胺酶抑制剂复合制剂(BLICs)的敏感性高,鲍氏不动杆菌和铜绿假单胞菌对碳青霉烯类的耐药率约为12.0%,对BLICs的敏感性高;耐甲氧西林凝固酶阴性葡萄球菌和耐甲氧西林金黄色葡萄球菌的分离率分别为94.7%和70.4%,未检出耐万古霉素葡萄球菌和肠球菌。结论分析血液病患者医院感染的病原菌分布特点及耐药性对临床经验性用药有一定的参考价值。
OBJECTIVE To investigate the distribution and drug resistance of pathogens in hematology wards, as well as for better empirical antibiotic therapy. METHODS The distribution of clinical isolated pathogen of the patients in hematological wards from Jan 2007 to Dec 2010 were analyzed. RESULTS Totally 455 strains of pathogens were isolated, Gram-negative bacteria remained the predominant pathogen, Gram-positive cocci infection decreased gradually during the four years. Escherichia coli was the most common pathogenic bacteria. Extended spectrum betalactamase（ESBLs） producing rates of Escherichia coli and Klebsiella pneurnoniae were 61.1%and 38.3%, respectively. Carbapenems and β-Lactamase inhibitors had high activity for E. coli, the drug resistance rates of Acinetobacter baumannii and Pseudomonas aeruginosa to carbapenems were 12.0 %, but susceptible to β- Lactamase inhibitors. The detected rates of the coagulase-negative Staphylococci and methicillin-resistant S. au- reus were 94. 7% and 70. 4%, respectively, Neither vancomycin-resistant strains of Staphylococcus. nor Enterococeu were found. CONCLUSION The data is important and valuable for the empirical antibiotic therapy for infections in hospitalized patients with hematological diseases.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第24期5291-5294,共4页
Chinese Journal of Nosocomiology
关键词
血液病
医院感染
病原菌
耐药性
Hematological disease
Nosocomial infection
Pathogen
Drug resistance
