摘要
目的了解2008-2010年产科病房孕产妇围生期生殖道感染病原菌的构成特点及其耐药性变化,为临床合理使用抗菌药物提供依据,并为加强控制医院感染的发生提供实验室诊断。方法对产科病房2008-2010年生殖道标本所分离出的病原菌及其耐药性进行回顾性调查分析。结果送检标本共2047份,检出病原菌88株,检出率4.3%;前4位病原菌依次为大肠埃希菌、金黄色葡萄球菌、肺炎克雷伯菌、无乳链球菌,分别占28.4%、26.2%、10.2%、6.8%;金黄色葡萄球菌、革兰阴性杆菌和链球菌属对常用抗菌药物耐药较为严重,且呈多药耐药性,耐甲氧西林金黄色葡萄球菌(MRSA)检出率为21.7%,革兰阴性杆菌产超广谱β-内酰胺酶(ESBLs)检出率为17.4%。结论进行病原学监测,了解病原菌构成及其耐药趋势,对合理选择抗菌药物、降低围生期生殖道细菌感染发生率、减少耐药菌株产生和控制医院感染暴发和流行均有重要价值。
OBJECTIVE To investigate the composing characteristics and drug resistances of pathogens isolated from genital tracts in perinatal period of obstetrics patients from 2008 to 2010, for instructing clinical application of antibiotics reasonably and controlling father the occurrence of nosocomial infection. METHODS A retrospective investigation analysis was made for all the isolated bacteria from genital tracts specimens as well as their drug resistances from 2008 to 2010. RESULTS The results showed that 88 strains of bacterial pathogens were isolated from 2047 detected samples. Escherichia coli , Staphylococcus aureus , Klebsiella pneumoniae and Streptococcus aglactiae were the most frequently isolated pathogens. G- bacilli and S. aureus and Streptococcus spp were highly resistant to commonly used antibiotics and demonstrated multi-drug resistance. The methicillin resistant S. aureus （MRSA） was 21. 7%. The extended-spectrum beta-lactamases （ESBLs） producing strains in G- bacilli was 17.4%. CONCLUSIONS Inspecting pathogens and studying the composition of pathogens and the trend of their drug resistance are important to rationally select antibiotics, reduce incidence of genital tracts bacterial infection and decrease the occurrence of drug resistant strains in perinatal period, and control the outbreak and prevalence of nosocomial infection.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第24期5305-5307,共3页
Chinese Journal of Nosocomiology
关键词
围生期
生殖道
病原菌
构成
耐药性
Perinatal period
Genital tract
Bacterial pathogen
Composition
Drug resistance
