摘要
目的探讨血清胱抑素C(Cys-C)及几多项血清指标(NT-proBNP、肌钙蛋白T、超敏C反应蛋白、肌酐等)在急性心力衰竭(AHF)患者中的表达水平和评价其预后价值及相关性。方法入选2007～2009年因急性心力衰竭患者136例,入院即测定Cys-C、NT-proBNP、c-TNT、hs-CRP、SCr等多项血清学指标观察其表达水平。平均随访1年,记录各组心脏全因死亡率和因心衰再次住院率,评价各项指标对急性心衰预后预测价值及相关性。结果 136名患者中61名发生不良临床事件,随着Cys-C浓度升高发生率增加(分别为29.3%、40.8%、63.1%,P<0.05);且Cys-C、NT-proBNP、c-TNT同时升高的数量越多,发生率也随之增加(分别为38.1%,44.2%,67.7%,P<0.05)。结论 Cys-C、NT-proBNP、c-TNT具有独立预测价值,而联合三者对急性心力衰竭进行危险评估可提高其预测价值,有助于识别高危患者。
Objective To evaluate the prognostic value of cystatin C and some of serum markers（NT-pro-BNP,c-TnT,Hs-CRP,creatinine,etc.） in the risk stratification of an unselected cohort of patients with acute heart failure.Methods 136 hospitalized patients with established diagnoses of acute heart failure were prospectively studied.Blood samples were collected on hospital arrival to determine Cys-C、NT-proBNP、c-TNT、hs-CRP、SCr ete.Clinical follow-up（1 year） was obtained,and the occurrence of mortality and/or heart failure readmission was regist.Results 61 patients（44.9%） presented with adverse events,,and with the Cys-C concentration increased,the incidence increased（respectively 29.3%,40.8%,63.1% P 0.05）;At the same time the more increasing number of Cys-C,NT-proBNP,c-TNT,the more increasing incidence（respectively 38.1%,44.2%,67.7% P 0.05）.Conclusion Cys-C,NT-pro-BNP,c-TNT has independent predictive value,and the three joint risk assessment of acute heart failure can improve their predictive value,help to identify high-risk patients.
出处
《当代医学》
2011年第36期21-22,共2页
Contemporary Medicine
