摘要
2,6-二氯-4-硝基苯胺经重氮化、氯代及还原得到3,4,5-三氯苯胺,再以N,N′-二(乙氧羰基)丙二酰胺为环合剂,经重氮化、偶联、闭环、水解及脱羧反应制得具有抗球虫活性的2-(3,4,5-三氯苯基)-1,2,4-三嗪-3,5(2H,4H)-二酮,总收率约39%(以2,6-二氯-4-硝基苯胺计)。
2-（3,4,5-Trichlorophenyl）-1,2,4-triazine-3,5 （2H,4H）-dione was synthesized from 2,6-dichloro- 4-nitroaniline by diazotization, chlorination and reduction to give 3,4,5-trichloroaniline, which was subjected to diazotization and coupling with N,N ＇-bis （ethoxycarbonyl） malonamide, cyclization, hydrolysis and then decarboxylation with an overall yield of about 39 % （based on 2,6-dichloro-4-nitroaniline）.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2011年第12期889-891,共3页
Chinese Journal of Pharmaceuticals
基金
国家高技术研究发展计划(863计划)项目(2011AA10A214)
