摘要
在微乳配方开发过程中,通常选用短链醇作为助表面活性剂,然而有些药物在这些助表面活性剂中的溶解度或相容性并不理想。因此,选用非醇类物质(Plurol^(?) Oleique CC 497、Capyrol^(TM) 90或Transcutol^(?))为助表面活性剂,并以Labrasol^(?)为表面活性剂,Labrafil^(?)M 1944为油相,分别绘制了空白微乳的伪三元相图。结果表明,这些助表面活性剂的种类和表面活性剂/助表面活性剂比例(K_m)对o/w型微乳的形成有影响。
Short-chain alcohols were commonly used as co-surfactant in the formulation design of microemulsions. However, the solubility or compatibility of some drugs in these co-surfactants were not satisfactory. Thus, the pseudo-ternary phase diagrams of blank microemulsions with non-alcohol material （Plurol Oleique CC 497, CapyrolTM 90 or Transcutol ） as co-surfactant, Labrasol as surfactant and Labrafil M 1944 as oil were drawn. The results showed that the kind of co-surfactant and the ratio of surfactant/co-surfactant （Kin） could affect the formation of oil-in-water microemulsions.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2011年第12期907-909,共3页
Chinese Journal of Pharmaceuticals
