摘要
目的 评价小牛血去蛋白提取物眼用凝胶治疗LASIK术后干眼症的临床治疗效果。方法取2008年1月至2009年12月间在行LASIK手术后发生干眼症的单纯近视及近视散光患者76例(152只眼),采用自身对照法,每例随机选取一只眼进入治疗组(小牛血去蛋白提取物眼用凝胶滴眼);另一只眼进入对照组(0.1%玻璃酸钠滴眼液滴眼)。术后1d、1周、1月、3月观察眼部不适主诉、ShirmerI试验、BUT、荧光素染色结果。结果眼部不适主诉术后1周、1月实验组明显低于对照组(P〈0.05);ShirmerI试验术后1周、1月实验组明显长于对照组(P〈0.05);BUT术后1周、1月、3月实验组明显长于对照组(P〈0.05);荧光素染色分级术后1d和1月实验组明显低于对照组(P〈0.05)。结论小牛血去蛋白提取物眼用凝胶治疗LASIK术后干眼症疗效确切、起效时间短、能够有效改善患者不适症状及体征。
Objective To evaluate the treatment effect of expression of protein-free calf blood extract gel in dry eyes after LASIK. Methods A total of 76 cases (152 eyes) of dry eye after LASIK were collected for study. Each case was chosen one eye into experiment group (treated with protein-free calf blood extract gel) and the other eye into control group (treated by 0.1% sodium hyaluronate drop) at random. The discomfortness of eyes, Shirmer I test, tear breaking-up time (BUT) and fluorescent bangle staining of cornea were tested and marked after 1 day, 1 week, 1 month and 3 months after LASIK. Results Between experiment group and control group, the discomfortness of eyes were significant less in experiment group at 1 week and 1 month after LASIK (P 〈0.05); the Shirmer I test wetting were significant length at 1 week and 1 month after LASIK (P 〈0.05); the BUT were significant longer at 1 week, 1 month and 3 months after LASIK (P 〈0.05); the level of fluorescent bangle staining of cornea were significant reduced at 1 day and 1 month after LASIK (P 〈0.05). Conclusions Protein-free calf blood extract gel can be used to improve on the symptom,objective sign in dry eyes after LASIK.
出处
《中国实用眼科杂志》
CSCD
北大核心
2011年第12期1258-1260,共3页
Chinese Journal of Practical Ophthalmology