摘要
蛋白尿不仅是糖尿病肾病(DN)的监测指标,也是其重要的可调节指标,控制蛋白尿的排泄与肾脏的预后有着紧密联系。治疗后的蛋白尿下降程度和残余蛋白尿同初始蛋白尿一样重要,是肾脏预后的重要标志,所谓残余蛋白尿,目前没有公认的定义,依据诸多学者的表述是指即使充分使用肾素血管紧张素系统(RAS)阻滞剂,蛋白尿水平仍旧无法下降甚至控制到正常水平,
出处
《中华医学杂志》
CAS
CSCD
北大核心
2011年第44期3158-3160,共3页
National Medical Journal of China
基金
国家自然科学基金(81070649)
参考文献27
-
1林洪丽,张靖华.RAS阻断剂在蛋白尿治疗中的应用[J].临床肾脏病杂志,2010(7):330-331. 被引量:2
-
2Kelly DJ,Zhang Y,Moe G,et al.Aliskiren,a novel renin inhibitor,is renoprotective in a model of advanced diabetic nephropathy in rats.Diabetologia,2007,50:2398-2404.
-
3Parving HH,Persson F,Lewis JB,et al.Aliskiren combined with losartan in type 2 diabetes and nephropathy.N Engl J Med,2008,358:2433-2446.
-
4Dong YF,Liu L,Lai ZF,et al.Aliskiren enhances protective effects of valsartan against type 2 diabetic nephropathy in mice.J Hypertens,2010,28:1554-1565.
-
5Diaz VA,Mainous AG,Carek PJ,et al.The association of vitamin D deficiency and insufficiency with diabetic nephropathy:implications for health disparities.J Am Board Fam Med,2009,22:521-527.
-
6de Zeeuw D,Agarwal R,Amdahl M,et al.Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study):a randomised controlled trial Lancet,2010,376:1543-1551.
-
7Zhang Z,Sun L,Wang Y,et al Renoprotective role of the vitamin D receptor in diabetic nephropathy.Kidney Int,2008,73:163-171.
-
8Zhang Z,Zhang Y,Ning G,et al.Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy:blockade of compensatory renin increase.Proc Natl Acad Sci U S A,2008,105:15896-15901.
-
9Sasaki T,Kurata H,Nomura K,et al.Amelioration of proteinuria with pravastatin in hypercholesterolemic patients with diabetes mellitus.Jpn J Med,1990,29:156-163.
-
10Fujii M,Inoguchi T,Maeda Y,et al Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice.Kidney Int,2007,72:473-480.
二级参考文献45
-
1廖琳,周新丽,王熙宁,赵家军.前列腺素E_1治疗糖尿病下肢血管病变疗效观察[J].山东医药,2005,45(7):40-41. 被引量:13
-
2曲勇,潘振宇,辛颖,杨明,韩文霞,邢海燕,廖琳.前列腺素E1对糖尿病肾病大鼠肾脏细胞凋亡的影响及其机制的研究[J].细胞与分子免疫学杂志,2006,22(6):774-776. 被引量:16
-
3宋利格,李颖,周筠,陈亚青,李红,张秀珍.α-硫辛酸对糖尿病周围神经病变的疗效[J].中华内分泌代谢杂志,2007,23(2):166-167. 被引量:92
-
4Seligman BG, Biolo A, Polanczyk CA, et al. Increased plasma levels of endothelin 1 and yon Willebrand factor in patients with type 2 diabetes and dyslipidemia. Diabetes Care, 2000,23 : 1395-1400.
-
5Coen DA. Endothelial dysfunction in diabetic nephropathy: state of the art and potential significance for non-diabetic renal disease. Nephrol Dial Translant, 2004,19:778-781.
-
6Akasaka N, Yamazaki K, Ishikawa M, et al. Lipo-prostaglandin El is absorbed by vascular smooth muscle cells and may enhance re-endothelialization of vein grafts. Cardiovasc Surg (Torino), 2002, 43.. 869-875.
-
7Ergul A, Johansen JS, Stromhaug C, et al. Vascular dysfunction of venous bypass conduits is mediated by reactive oxygen species in diabetes: role of endothelinl. Pharmacol Exp Ther,2005,313 : 70-77.
-
8Remuzzi G, Bertani T. Pathophysilogy of progressive nephropathies. N Engl J Med,1998,39:1448.
-
9Dominguec JH,Tang N,Xu W,et al. Studies of renal injury 19: Lipid induced nephropathy in type Ⅱ. Kidcy Int,2002, 3:196-198.
-
10Huang JS, Guh JY, Hung WC, el al. Role of the Janus kinase(JAK)/signal transduclets and activators of transcription ( STAT ) cascade in advanced glycation end product induced cellular mitogenesls in NKK-49F cells. Biechem J,1999,342(Pt1) :231-238.
共引文献55
-
1李艳艳,张迎春.前列地尔联合血塞通注射液对早期糖尿病肾病尿蛋白的影响[J].医学信息(医学与计算机应用),2014,0(30):77-78. 被引量:1
-
2田嘉嘉.α硫辛酸治疗2型糖尿病早期肾病疗效观察[J].医学信息(医学与计算机应用),2014,0(26):635-636. 被引量:1
-
3胡怡,刘立旻,张斌,高阳,熊盈,魏敏,毛宇强,陈松,陈思娇,宋今丹.醛固酮拮抗剂对代谢综合征合并慢性心力衰竭患者胰岛素抵抗指数和C-反应蛋白的影响[J].中国全科医学,2008,11(15):1332-1334. 被引量:10
-
4冯波,颜新凤,薛俊丽,徐雷.2型糖尿病大鼠肾脏病变与线粒体功能变化关系[J].同济大学学报(医学版),2009,30(5):29-31. 被引量:1
-
5王庭俊,王中心,杨芳,陈纯娴.舒洛地特治疗2型糖尿病早期肾病的临床观察[J].医药世界,2009(12):769-771. 被引量:2
-
6李鹏飞,牟亚汝,辛颖,曲勇,廖琳.前列腺素E1治疗糖尿病肾病1年的随访研究[J].南方医科大学学报,2010,30(3):482-485. 被引量:29
-
7高阳,陈思娇,杨红艳,李红燕,朱贺,郭英华,宋今丹.糖尿病肾病患者尿微量清蛋白与肌酐比值的相关因素研究[J].中国全科医学,2011,14(6):598-600. 被引量:41
-
8孔海鸿.罗格列酮联合厄贝沙坦治疗早期糖尿病肾病临床分析[J].齐齐哈尔医学院学报,2011,32(8):1240-1241. 被引量:5
-
9熊凤琴.慢性肾炎蛋白尿48例诊疗观察[J].吉林医学,2011,32(16):3227-3228. 被引量:1
-
10韩亚娟,高方,薛耀明,李际敏,孟敏.α-硫辛酸注射液联合前列地尔治疗糖尿病周围神经病变的疗效观察[J].广东医学,2011,32(18):2464-2466. 被引量:57
同被引文献36
-
1全国eGFR课题协作组.MDRD方程在我国慢性肾脏病患者中的改良和评估[J].中华肾脏病杂志,2006,22(10):589-595. 被引量:708
-
2Schmidt MI, Hadji-Georgopoulos A, Rendell M,et al. Thedawn phenomenon, an early morning glucose rise : implicationsfor diabetic intraday blood glucose variation [ J]. DiabetesCare,1981,4(6) ;579-585.
-
3Sung JY,Park SB,Liu YT,et al. Progressive axonal dysfunc-tion precedes development of neuropathy in type 2 diabetes[J]. Diabetes,2012,61 (6) :1592-1598.
-
4Rybicka M,Krysiak R,Okopien B. The dawn phenomenon andthe Somogyi effect-two phenomena of morning hyperglycae-mia [Jj.Endokrynol Pol,2011,62(3) :276-284.
-
5Navarro-González JF,Mora-Fernández C,Muros de Fuentes M,et al.Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy[J].Nat Rev Nephrol,2011;7(6):327-40.
-
6Fitzpatrick DC,Sheerin DV,Wolf BR,et al.A randomized,prospective study comparing intertrochanteric hip fracture fixation with the dynamic hip screw and the dynamic helical hip system in a community practice[J].Iowa Orthop J,2011;31(2):166-72.
-
7Azar D,Mohsen J,Shila K.Effects of antenatal corticosteroids on maternal serum indicators of infection in women at risk for preterm delivery:a randomized trial comparing betamethasone and dexamethasone[J].J Res Med Sci:Official J Isfahan Uni Med Sci,2012;17(10):911-7.
-
8Mega C,de Lemos ET,Vala H,et al.Diabetic nephropathy amelioration by a low-dose sitagliptin in an animal model of type 2 diabetes(Zucker Diabetic Fatty Rat)[J].Exp Diabet Res,2011;16(20):92.
-
9Hunziker S,Hugle T,Schuchardt K,et al.The value of serum procalcitonin level for differentiation of infections from noninfectious causes of fever after orthopedic surgery[J].Bone Joint Surg,2010;92(1):138-48.
-
10Cheng T,Zhang G,Zhang X.Review:minimally invasive versus conventional dynamic hip screw fixation in elderly patients with intertrochanteric fractures:a systematic review and meta-analysis[J].Surg Innov,2011;18(2):99-105.
引证文献6
-
1杜强,邵洋.中效胰岛素治疗糖尿病黎明现象的疗效观察[J].实用药物与临床,2012,15(10):626-627. 被引量:2
-
2廖淑金,杨川,江慧琦,黄萍,严励.前列地尔治疗高龄糖尿病并慢性肾脏病患者疗效和安全性[J].中山大学学报(医学科学版),2015,36(1):120-125. 被引量:104
-
3金洁娜,孙慧燕,徐赵钕,林昭宇,陶凯.西格列汀对老年糖尿病肾病患者临床指标的影响[J].中国老年学杂志,2016,36(1):79-81. 被引量:11
-
4金洁娜,孙慧艳,徐赵钕,林昭宇,陶凯.前列地尔治疗早期糖尿病肾病疗效及安全性观察[J].重庆医学,2016,45(10):1337-1338. 被引量:84
-
5王媛媛,李惠莉,李元梅,应慧敏,田芳,成伯宁.西格列汀对2型糖尿病肾病2期患者的影响[J].浙江实用医学,2018,23(3):176-179. 被引量:1
-
6李小刚.复方α-酮酸联合低蛋白饮食对糖尿病肾病患者的肾功能影响[J].医药前沿,2020,10(9):31-33. 被引量:2
二级引证文献202
-
1黄柏机,赵念,徐霜.前列地尔治疗高龄糖尿病合并慢性肾脏病患者的效果观察[J].临床合理用药杂志,2020,13(5):63-64. 被引量:1
-
2孙兴华.前列地尔联合厄贝沙坦治疗慢性肾小球肾炎的临床价值体会[J].世界最新医学信息文摘,2020(28):134-135. 被引量:2
-
3Hai-Xia Li,Shu-Juan Liu.Assessment of the renal function, peroxidation damage and inflammatory injury after epalrestat combined with alprostadil treatment of early diabetic nephropathy[J].Journal of Hainan Medical University,2017,23(5):29-32.
-
4贾复.关于水气界面处的气体传输[J].力学进展,2000,30(1):66-76. 被引量:11
-
5蔡正维,刘孝桥,熊安秀,王敏,张光环,李红义,高琴峰.胰岛素和左旋多巴联合激发试验对儿童生长激素缺乏症的诊断价值[J].实用医学杂志,2013,29(16):2732-2734. 被引量:14
-
6覃东红,黄海珍,蔡月娣,卢逊陈,陈敏.前列地尔对糖尿病患者椎动脉供血不足引起的眩晕的临床疗效[J].中国医药科学,2018,8(24):41-43.
-
7陈文涛,汪团珠.前列地尔治疗早期糖尿病肾病疗效及安全性研究[J].实用糖尿病杂志,2019,15(1):40-41. 被引量:2
-
8张芳.前列地尔治疗高龄糖尿病合并慢性肾脏病的安全性[J].北方药学,2015,12(8):128-129. 被引量:16
-
9毕瑞玲.前列地尔治疗高龄糖尿病并慢性肾脏病患者疗效和安全性[J].世界最新医学信息文摘,2015,15(35):71-71. 被引量:28
-
10杨银伟,赵亚君,卫靑园.探讨前列地尔治疗80岁以上糖尿病合并慢性肾脏病患者的疗效及安全性[J].中国现代药物应用,2015,9(18):174-175. 被引量:21
-
1刘非凡,陈香美,廖洪军.肾素血管紧张素系统及其受体在肾内的分布和功能[J].国外医学(泌尿系统分册),1994,14(4):177-179. 被引量:1
-
2潘雪芳.高压氧辅助治疗断指再植36例分析[J].广州医药,2004,35(1):72-72. 被引量:1
-
3尿白蛋白排泄率对慢性肾脏病患者心血管及肾脏预后的影响[J].中华医学信息导报,2009,24(1):10-10.
-
4张国华,张训,侯凡凡.肾素血管紧张素系统与肾间质纤维化[J].国外医学(生理病理科学与临床分册),1999,19(6):530-532. 被引量:4
-
5谢盛彬,陈楠.维生素D减轻肾间质纤维化的机制[J].肾脏病与透析肾移植杂志,2010,19(2):164-167.
-
6涂晓文,陈香美.阻断肾素血管紧张素系统对慢性肾脏疾病的治疗作用[J].中华肾脏病杂志,2006,22(1):54-56. 被引量:43
-
7肾素血管紧张素系统抑制剂单药或联合用药对肾病尿蛋白的影响[J].中华高血压杂志,2008,16(5):478-478.
-
8温绍君,王金城,张维君,周其文.肾素血管紧张素系统与冠状动脉旁路移植术[J].中国医药导刊,2001,3(3):190-191. 被引量:1
-
9施蓓莉,倪兆慧.进展性IgA肾病的治疗进展[J].临床药物治疗杂志,2012,10(5):25-28. 被引量:1
-
10闫志群,李六生,周志华,刘兰香.阿法骨化醇对IgA肾病患者血清TNF-α、IL-6、TGF-β1水平的影响[J].中国医药导报,2016,13(8):150-153. 被引量:4