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早期负荷剂量阿托伐他汀对急性冠脉综合征患者预后的影响 被引量:12

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摘要 目的观察急性冠脉综合征(ACS)患者早期使用负荷剂量阿托伐他汀的安全性及预后。方法将ACS患者60例随机分为常规剂量组30例及负荷剂量组30例。常规剂量组给予阿托伐他汀20 mg/d口服,负荷剂量组予阿托伐他汀40 mg/d口服。分别测治疗前及治疗2周后血脂、高敏C反应蛋白(hs-CRP)、肝功能、心肌酶水平,并随访6个月,统计严重心血管不良事件(MACE)发生情况。结果治疗2周后负荷剂量组较常规剂量组血脂、hs-CRP水平下降更明显,负荷剂量组心血管严重事件发生情况少于常规剂量组。2组肝功能无明显损害,无肌病发生。结论早期使用负荷剂量阿托伐他汀能改善ACS患者的预后,且不降低药物使用的安全性。
作者 陈兴国
出处 《现代中西医结合杂志》 CAS 2012年第1期36-38,共3页 Modern Journal of Integrated Traditional Chinese and Western Medicine
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参考文献7

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