摘要
目的探讨支气管哮喘患儿血清IgE和TNF-α检测的临床意义。方法观察32例支气管哮喘急性发作期患儿治疗前后血清IgE和TNF-α的动态变化,并与28例正常健康儿童进行比较。结果哮喘发作期患儿血清IgE和TNF-α含量均明显高于对照组(P<0.01);哮喘症状明显缓解后14 d患儿IgE和TNF-α含量较哮喘发作期明显下降(P<0.01),但仍较对照组高(P<0.05);TNF-α与IgE含量呈正相关(r=0.597,P<0.01)。结论临床检测IgE和TNF-α含量可作为判断支气管哮喘病情严重程度和治疗效果的重要指标。
Objective To observe the clinical value of detecting tumor necrosis factor-α （TNF-α） and igE contents in children with bronchial asthma. Methods The levels of serum IgE and TNF-α were measured in 32 children with bronchial asthma both during acute attack and after treatment（14 days later）. 28 normal healthy children were compared as controls. Results The levels of serum lgE and TNF-α in children with bronchial asthma during asthma attack were significantly higher than those in controls （P 〈0. 01 ）. The levels of serum IgE and TNF-α in children with bronchial asthma treatment aider 14 d turther decreased than those in children with bronchial asthma during asthma attack （P 〈 0. 01 ） , but still remained higher than those of controls（P 〈 0. 05 ）. Significantly positiw; relationship was observed between IgE and TNF-α levels （ r = 0. 597,P 〈 0.01 ）. Conclusion The clinical detection of IgE and TNF-α levels are useful for assessment of the therapeutic efficacy.
出处
《临床肺科杂志》
2012年第1期50-51,共2页
Journal of Clinical Pulmonary Medicine
