摘要
采用浓硫酸为催化剂,以D-葡萄糖-13C6和丙酮为原料合成了13C6-1,2:5,6-O-双异丙叉-α-D-呋喃葡萄糖,并对其进行了气相色谱(GC)、质谱(MS)分析。对合成条件进行了优化,优化后的合成条件为:葡萄糖与丙酮的摩尔比为1∶73.5,浓硫酸用量为10mL,反应温度25℃,反应时间12h,优化条件下合成的13C6-1,2:5,6-O-双异丙叉-α-D-呋喃葡萄糖收率为75.6%,产品中13C丰度为99.2%,纯度为98.7%。
With concentrated sulfuric acid as the catalytic agent, ^13C6-1,2：5,6-O-isopropylidene-α-D-glucofuranose was synthesized with D-glucose-^13C6 and acetone, ^13C labeled 1, 2：5,6-Di-O--isopropylidene-α-D-glucofuranose was characterized by GC and MS. The reaction conditions were optimized to be as follows： the molar ratio of [D-glucose-^13C6 ] ： [acetone-] = 1 ： 73.5, the volume of concentrated sulfuric acid = 10 mL, the reaction temperature = 25 ℃, and the reaction time = 12 h. Under these conditions, the yield of ^13C6-1,2： 5,6-Di-O-isopropylidene-α-D-glucofuranose was 75. 6% （based on D-glucose-13 C6）, with 99.2%^13C .atom abundance and 98.7% chemical purity.
出处
《同位素》
CAS
2011年第4期229-233,共5页
Journal of Isotopes
基金
国家高新技术研究发展计划项目(2008AA02Z427)
