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血清降钙素原与C反应蛋白联合检测在新生儿感染性疾病中的应用 被引量:26

Application of the Combined Determination of Serum Procalcitionin and C-reactive Protein in Neonate with Infection
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摘要 目的:评价降钙素原(procalcition,PCT)与C反应蛋白(C-reactive protein,CRP)联合检测对新生儿感染性疾病的诊断及病情评估的价值。方法:选择2008-2010年入院的60例细菌性感染的新生儿,分为重症感染组32例和局部感染组28例,检测患儿血清PCT、CRP的含量及动态变化,并与30例非感染组进行比较。结果:重症感染组血清PCT、CRP浓度平均值分别为25.3μg/L和24.3mg/L;局部感染组血清PCT、CRP浓度平均值分别为3.5μg/L和15mg/L,与非感染组相比,差异有统计学意义(P<0.001);经有效的抗菌治疗后,细菌感染组患儿的PCT、CRP浓度均下降,与治疗前相比,差异有统计学意义(P<0.001);PCT的敏感性和CRP相似(93.3%),PCT的特异性(83.3%)高于CRP(63.3%)。结论:PCT、CRP联合检测对新生儿细菌性感染的早期诊断有重要价值,PCT的特异性要优于CRP,动态检测PCT水平有助于评估治疗效果,协助判断疾病的转归。 Objective:To evaluate the clinical value of the combined determination of serum procalcitonin(PCT)and C reactive protein(CRP)in the diagnosis and curative effect in neonate with infection.Methods:60 infants in our hospital from 2008 to 2010 with bacterial infection were enrolled in the study which were classified into serious infection group and local infection group.Serum PCT and CRP levels and their dynamic change were measured,and the results were analyzed and compared with those of non-infection group.Results:The mean value of PCT and CRP concentrations in serious infection group were 25.3μg/L and 24.3mg/L.In local infection group,the mean value were 3.5μg/L and 15mg/L respectively,and there were statistical significance compared to non-infection group(P0.001,0.001);After the antibiotic treatment,the levels of PCT and CRP decreased significantly(P0.001);The sensitivity of PCT was similar with that of CRP(93.3%),the specificity of PCT(83.3%)was better than that of CPR(63.3%).Conclusion:The conbined determination of PCT and CRP assists the early diagnosis and prognosis of bacterial infection in neonate.The specificity of PCT was better than that of CRP.Monitoring dynamically PCT level will help to evaluate the curative effect.
出处 《医学理论与实践》 2011年第23期2796-2797,共2页 The Journal of Medical Theory and Practice
关键词 降钙素原 C反应蛋白 新生儿 Procalcitionin C-reactive protein Neonate
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  • 1苏卫东,徐克,瞿尔力,黄育丹,藤碎龙,包曼华.新生儿严重感染血清降钙素原监测的临床意义[J].临床医学,2006,26(4):66-67. 被引量:33
  • 2俞娅芬,陈德昌,宋秀琴.早期诊断严重脓毒症 脓毒性休克研究进展[J].中国急救医学,2007,27(2):154-156. 被引量:56
  • 3Mirjam Christ-Crain, Beat Miiller. Procalcitonin in bacterial infections-hype, hope, more or less [J]? Swiss Med Wkly, 2005, 135: 451--460.
  • 4Muller B, White JC, Nylen E, et al. Ubiquitous expression of the ealcitortin-1 gene in multiple tissues in response to sepsis [J]. J Clin Endocrinol Metab, 2001, 86: 396-404.
  • 5Philippe Linseheid, Dalma Seboek, Eric S. Nylen, et al. In Vitro and in Vivo Caleitonin I Gene Expression in Parenchymal Cells: A Novel Product of Human Adipose Tissue [J]. Endocrinology, 2003, 144: 5578-5584.
  • 6Meisner M., Procalcitonin (PCT) A new, innovative infection parameter.; Biochemical and clinical aspects; ISBN: 3-13- 105503-0 [S]. Thieme Stuttgart, New York, 2000.
  • 7Mirjam Christ-Crain, Dalana Stolz, Roland Bingisser, et al. Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia [J]. American journal of respiratory and critical care medicine, 2006, 174: 84-93.
  • 8Daiana Stolz, Miriam Christ-Crain, Roland Bingisser, et al. Antibiotic Treatment of Exacerbations of COPD [J]. Chest, 2007, 1 : 9-19.
  • 9Christ-Crain M, Jaccard-Stolz D, Bingisser R, et al. Effect of procalcitanin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial [J]. Lancet, 2004, 363: 600-607.
  • 10Jens Ulrik Jensen, Lars Heslet, Tom Hartvig Jensen et al. Procalcitonin increase in early identifucation of critically ill patients at high risk of mortality [J]. Crit care med, 2006, 34: 2596-2602.

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