摘要
失重环境引起力学负荷的消失对骨的力学性能会产生消极影响,超重环境同样会引起骨力学性能的改变。体内骨细胞是感应力学载荷的主要细胞,对机械应力的变化十分敏感,通过参与调控骨形成和骨吸收以调节骨的力学适应性。本文综述了正常重力下骨细胞对力学刺激的生物学响应以及对成骨细胞和破骨细胞的调控,同时对微重力和超重下骨细胞力生物学方面的研究进展作了回顾。
The disappearance of mechanical load in space could result in negative impact on the mechanical properties of bone, which were also changed under the hypergravity environment. Osteoeyte was the chief cell that could sense the mechanical stimulation and was considered to be very sensitive cell with response to the change of mechanical stress. Osteocyte could adjust the mechanical adaptation of bone through regulating bone formation and bone resorption. In this paper, the biological responses to mechanical stimulation of osteocytes under 1 G were reviewed as well as their regulative effects on osteoblasts and osteoclasts. Meanwhile, mechanobiological researches on osteocytes under microgravity and hypergravity environments were also reviewed.
出处
《航天医学与医学工程》
CAS
CSCD
北大核心
2011年第6期398-402,共5页
Space Medicine & Medical Engineering
基金
国家自然科学基金项目(10872024)
关键词
骨细胞
力学刺激
微重力
超重
osteocytes
mechanical stimulation
microgravity
hypergravity
