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五环三萜皂苷抗肿瘤作用及其机制的研究进展 被引量:1

Advances in Antitumor Activity of Pentacyclic Triterpenoids
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摘要 肿瘤是严重威胁人类健康的一类疾病。一些五环三萜皂苷具有很好的抗肿瘤作用,且其抗肿瘤机理也表现在多个方面,主要包括抗突变、抑制细胞增殖和诱导细胞凋亡、抑制肿瘤血管生长、抗炎和诱导肿瘤细胞分化等。对近几年来文献中报道的,具有明确化学结构,并且在体内外实验中显示有确切抗肿瘤作用的三萜皂苷进行了整理和综述。 Cancer threatens human health. Some pentacyclic triterpenoids have good antitumor activities, the mechanisms of which conclude antimutagenic effects,inhibition of cell growth, induction of apoptosis, inhibition of tumor angiogenesis, anti-inflammation,induction of cell differentiation, et al. This review summarized the antitumor activities and mechanisms of the triterpenoids.
作者 管福琴 冯煦
出处 《天然产物研究与开发》 CAS CSCD 2011年第B12期275-279,271,共6页 Natural Product Research and Development
基金 江苏省自然科学基金(BK2008353) “重大新药创制”科技重大专项“十一五”计划(2009ZX09103-397)
关键词 五环三萜皂苷 抗肿瘤 齐墩果酸 熊果酸 白桦酸 雷公藤红素 pentacyclic triterpenoids antitumor activity oleanolic acid ursolic acid betulinic acid celastrol
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