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甲状腺相关眼病眶组织中细胞因子的表达 被引量：1

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摘要 甲状腺相关眼病（TAO）是常见的眼眶疾病,是一类与Grave病密切相关的自身免疫紊乱。尽管确切自身免疫抗原尚不明确,典型的组织学特点为：眼外肌（EM）和眼眶脂肪（OF）的淋巴细胞浸润、眼外肌的增粗及眼眶脂肪体积的增加。[1]临床上,
作者 骆立夫 杨凤娟 王洁 崔极哲
机构地区 吉林大学第二医院眼科
出处 《中国实验诊断学》 北大核心 2011年第12期2182-2183,共2页 Chinese Journal of Laboratory Diagnosis
基金 吉林省科技发展计划支持项目(200705248)
关键词 甲状腺相关眼病 组织学特点 细胞因子 自身免疫紊乱 GRAVE病 淋巴细胞浸润 眼眶脂肪 眼眶疾病
分类号 R581.1 [医药卫生—内分泌] R771.3 [医药卫生—眼科]
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参考文献17

  • 1Kahaly G,Hansen C,Felke B,Dienes HP.Immunohistochemical staining of retrobulbar adipose tissue in Graves' ophthalmopathy[J].Clin Immunol Immunopathol,1994,73:53.
  • 2张学进,罗清礼,张美霞.白细胞介素对Graves眼病患者眼眶成纤维细胞的作用[J].四川大学学报（医学版）,2004,35(2):241-243. 被引量：6
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  • 7Yuji Hiromatsu,Dame Yang,et al,Cytokine Profiles in Eye Muscle Tissue and Orbital Fat Tissue from Patients with Thyroid-Associated Ophthalmopathy[J] The Journal of Clinical Endocrinology & Metabolism,2000,85(3):1194.
  • 8孙丰源,赵红,宋国祥,潘叶,张淑敏,畅继武.干扰素对眶成纤维细胞GAG生成的刺激作用[J].眼科研究,1998,16(1):21-23. 被引量：4
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二级参考文献10

  • 1[1]Hofbauer LC, Muhlberg T, Konig A, et al. Soluble interleukin-1 receptor antagonist serum levels in smokers and nonsmokers with Graves' ophthalmopathy undergoing orbital radiotherapy. J Clin Endocrinol Metab, 1997; 82(7):2244.
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  • 5[5]Lu R, Wang P, Wartofsky L, et al. Oxygen free radicals in interleukin-1beta-induced glycosami-noglycan production by retro-ocular fibroblasts from normal subjects and Graves' ophthalmopathy patients. Thyroid, 1999; 9(3):297.
  • 6[6]Cao HJ, Smith TJ. Leukoregulin up regulation of prostaglandin endoperoxide H synthase-2 expression in human orbital fibroblasts. Am J Physiol, 1999; 277(6 pt 1): 1075.
  • 7[7]Imai Y, Ibaraki K, Odajima R, et al. Analysis of proteoglycan synthesis by retro-ocular tissue fibroblasts under the influence of interleukin 1 beta and transforming growth factor-beta. Eur J Endocrinol, 1994; 131(6):630.
  • 8[8]Yang D, Hiromatsu Y, Hoshino T, et al. Dominant infiltration of T(H)1-type CD4+ T cells at the retrobulbar space of patients with thyroid-associated ophthalmopathy. Thyroid, 1999; 9(3):305.
  • 9[9]Hiromatsu Y, Yang D, Bednarczuk T, et al. Cytokine profiles in eye muscle tissue and orbital fat tissue from patients with thyroid-associated ophthalmopathy. J Clin Endocrinol Metab, 2000; 85(3):1194.
  • 10[10]Tan GH, Dutton CM, Bahn RS. 1996 Interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptor inhibit IL-1-induced glycosaminoglycan production in cultured human orbital fibroblasts. J Clin Endocrinol Metab, 1996; 81(2):449.

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中国实验诊断学
2011年 第12期

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