摘要
目的对比观察氟比洛芬酯和硬膜外吗啡用于阴式子宫切除手术术后镇痛效果。方法 60例ASAⅠ～Ⅱ级择期行阴式子宫切除手术的患者,随机分为空白对照组、氟比洛芬酯组和吗啡组,每组20例。分别于子宫切除术后硬膜外注射生理盐水5 mL,吗啡2 mg,静脉滴注氟比洛芬酯50 mg,分别记录术后2 h、4 h、8 h、12 h、24 h、48 h的视觉模拟评分(VAS)。当疼痛VAS评分大于4分时,口服双氯芬酸钾100～150 mg或哌替啶20～100 mg肌注止痛,观察药物用量和不良反应。结果空白对照组2 h、4 h、8 h、12 h的疼痛评分高于氟比洛芬酯组和吗啡组(P<0.05),氟比洛芬酯组和吗啡组组间比较,差异无统计学意义。3组24 h、48 h的疼痛评分差异无统计学意义。术后48 h内,空白对照组服用双氯芬酸钾的例数多于氟比洛芬酯组和吗啡组(P<0.05),氟比洛芬酯组和吗啡组患者术后未追加镇痛药;吗啡组的瘙痒发生率显著高于空白对照组和氟比洛芬酯组(P<0.01);吗啡组的恶心发生率明显高于空白对照组(P<0.05)。结论静注50 mg氟比洛芬酯可达到硬膜外2 mg吗啡同等的镇痛效果,且不良反应少。
Objective To observe the analgesic effects in patients after undergoing vaginal hysterectomy with intravenous injection of flurbiprofen axetil and morphine in epidura.Methods 60 patients undergoing vaginal hysterectomy were randomized divided into three groups：control group,flurbiprofen group and morphine group,20 patients for each group.After hysterectomy,epidural injection of saline 5 mL and morphine 2 mg,intravenous injection of flurbiprofen 50 mg were given respectively.The visual analogue scale（VAS）at 2 h,4 h,8 h,12 h,24 h,48 h after operation were recorded.When the VAS 4,oral diclofenac potassium 100~150 mg or pethidine 20~100 mg intramuscular injection were given,and the drug dose and adverse reactions were recorded.Results The control group had higher VAS scores than flurbiprofen group and morphine group at 2 h,4 h,8 h,12 h（P0.05）,and there was no difference between flurbiprofen group and morphine group.No significant difference was found in VAS between three groups at 24 h,48 h.In the 48 h after operation,analgesic doses of diclofenac potassium used in control group were higher than those of flurbiprofen group and morphine group（P0.05）,there was no additional diclofenac potassium used in flurbiprofen group and morphine group.The incidence of pruritus in morphine group was significantly higher than those of control group and flurbiprofen group（P0.01）,The incidence of nausea in morphine group was significantly higher than that of control group（P0.05）.Conclusion Intravenous flurbiprofen 50 mg can achieve the same analgesic effect of epidural morphine 2 mg with less adverse reactions.
出处
《实用药物与临床》
CAS
2011年第6期467-469,共3页
Practical Pharmacy and Clinical Remedies
关键词
氟比洛芬酯
阴式子宫切除
镇痛
Flurbiprofen axetil
Vaginal hysterectomy
Analgesia
