摘要
目的通过槐杞黄颗粒联合糖皮质激素治疗儿童原发性肾病综合征(PNS)与单纯糖皮质激素治疗儿童原发性肾病综合征的对比研究,探讨槐杞黄颗粒对肾病综合征患儿的疗效及其免疫调节作用,观察其不良反应。方法将40例原发性肾病综合征患儿随机分为2组,治疗组20例采用槐杞黄联合糖皮质激素治疗,对照组20例单独服用糖皮质激素治疗,观察两组患儿水肿消退、蛋白尿转阴时间;观察期内感染例数;两组患儿治疗前后体液免疫:IgA、IgM、IgG,细胞免疫:CD3、CD4、CD8、CD4/CD8的变化情况;槐杞黄颗粒的不良反应;观察周期:连续观察12周。结果治疗组尿蛋白转阴、水肿消退时间明显小于对照组(P<0.05),感染发生率小于对照组(P<0.05);治疗组患儿体液免疫及细胞免疫较对照组明显改善,IgG、CD3、CD4/CD8均增高(P<0.01);治疗组治疗后IgA、IgM有一定增高趋势,但与对照组比较,其差异无统计学意义(P>0.05);2例患儿出现恶心、呕吐、腹泻,未见皮疹、肝肾功能异常等不良反应。结论槐杞黄颗粒辅助治疗肾病综合征患儿,可以缩短水肿消退、蛋白尿转阴的时间,可以增强肾脏病患儿的免疫调节功能、减少感染发生的机会,进而增强激素疗效改善预后,同时在治疗过程中未出现明显的不良反应,临床证实是安全有效的辅助治疗药物。
Objective To investigate tile effects of Huaiqihuang granule on treatment, immune regulation and its side effect of pediatric primary nephrotic syndrome by the contrast research of Huaiqihuang granule puls glucocorticoid and glucocorticoid only. Methods 40 children with primary nephrotic syndrome were randomly tow groups. The treatment group（20 children） were teated with Huaiqihuang granule puls glucocorticoid, the contrast group （20 children） had glucocorticoid only. The follow were obseved ： the time of edema regression and prourine normal, the infected numbers and the change of cellular immunity （ CD3, CD4,CD8,CD4/CDS） and humoral immunity（IgA,IgM,IgG） before and after treatment. Observation period was twelve weeks. Results In the treatment group, the time of edema regression and prourine normal was shorter than that in the contrast group（ P 〈 0.05 ） , and the incidence rate of infection was lesser than in the contrast group（ P 〈 0. 05 ）. Tile levels of IgG, CD3 and CD4/CD8 were significantly increase in the treatment group ,the levels of IgA and IgM had increase trend, but had no Statistically significant difference in two group （P 〉 0. 05 ）. Tow groups had nausea, vomit, Diarrhea, no rash and the abnormal of liver and kidney function, there were no Statistically significant difference. Conclusion The adjuvant treatment of Huaiqihuang granule on primary nephrotic syndrome carl shorten the time of edema regression and prourine normal, enhance the immulogical regulation function, and decrease the chance of infection. Also the adjuvant treatment of Huaiqihuang granule enhance the curative effect of glucocorticoid and improve prognosis of the disease. There is no side effect in the process ,which confirm that Huaiqihuang granule is safety and effective adjuvant drug of prinmry nephrotic syndrome.
出处
《四川医学》
CAS
2011年第12期1870-1872,共3页
Sichuan Medical Journal
关键词
肾病综合征
槐杞黄颗粒
体液免疫
细胞免疫
儿童
nepbrotic syndrome
Huaiqlhuang granule
humoral immunity
cellular immunity
children
