摘要
目的 :研究静脉注射不同剂量亚砷酸注射液后 ,主成分三氧化二砷在兔体内的药物动力学特征。方法 :大白兔分别静脉注射亚砷酸注射液 0 .3,0 .95 ,3mg·kg-1后于各时间点耳静脉采血 ,分离血清 ,用原子荧光分析仪测定砷浓度 ,所得血药浓度 时间数据用 3P97药动学软件处理 ,求得药动学参数。结果 :亚砷酸注射液药 时曲线均符合二室模型T1/2α分别为 0 .10 81± 0 .0 0 9,0 .2 96 8± 0 .0 0 33,0 .89± 0 .14h ;T1/2 β分别为 9.9± 0 .3,12 .2± 0 .8h ,7.0± 0 .8h ;Cls分别为 ( 17.0± 0 .9)× 10 -5,( 13.0± 1.0 )× 10 -4 和 ( 33.6± 2 .3)× 10 -4 L·h·kg-1;AUC分别为 ( 176 6 .8± 5 7.4)、( 315 0 .0± 78.7)和 ( 45 48.5± 191.5 )mg·L-1·h-1。结论 :亚砷酸注射液在兔体内分布快 ,消除较缓慢 。
OBJECTIVE:To investigate the pharmacokinetics of As 2O 3 in rabbit after intravenous.METHODS:The serm was collected from rabbit by posterior auricular vein,which has been intravenously with arsenic trioxide 0.3 , 0.95 ,3 mg·kg -1 ,respectively.The concentration of As 2O 3 were determined by Atom Fluorometry spectra analysis and the data were analysed with the programe of 3P97 to get pharmacokinetic prarameters.RESULTS:The concentration time curves of As 2O 3 fitleda two compartment kinetic model,respectively.The main pharmacokinetic parameters of As 2O 3 after iv was 0.3 , 0.95 ,3 mg·kg -1 was as follows: T 1/2a was ( 0.1081 ± 0.09 ) h;( 0.2968 ± 0.0033 ) h;( 0.89 ± 0.14 ) h; T 1/2β was ( 9.88 ± 0.29 ) h;( 12.2 ± 0.8 ) h;( 6.9 ± 0.8 ) h; Cls was (17± 0.9 )×10 -5 ,(13±1)×10 -4 ,( 33.6 ± 2.33 )×10 -4 L·kg -1 ·h -1 and AUC was ( 1766 ± 57.4 ),( 3150.0 ± 78.7 ),( 4548.5 ± 191.5 ) mg·L -1 ·h -1 ;reslpectively.CONCLUSIONS:The distribution was rapid and elimination was slowor,it's pharmacokinetics were linear.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2000年第1期27-28,共2页
Chinese Journal of Hospital Pharmacy
关键词
亚砷酸注射液
药物动力学
原子荧光分析法
ailing Ⅰ injection
pharmcokinetics
atom fluorometry spectra analysis
