摘要
目的探讨癫痫患者发作严重程度与其血清c-反应蛋白（CRP）水平的相关性。方法197例癫痫患者药物治疗后，分为无发作组（n=70）、轻度发作组（n=48）、中度发作组（n=50）和重度发作组（n=29），测定197例患者静息期血清CRP水平。结果无发作组、轻度发作组、中度发作组和重度发作组患者血清CRP分别为（1．44±0．88）mg／L、（2．87±0．18）mg／L、（5．34±0．20）mg／L、（9．63±0．64）mg／L，四组间血清CRP水平总体差异有统计学意义（F=179．35，P〈0．01）；癫痫发作严重程度与血清CRP水平呈正相关性（相关系数rs=0．083，P〈0．01）。结论癫痫发作频度越高，其血清CRP水平越高；血清CRP水平可能是预测癫痫发作严重程度的一个指标。
Objective To investigate the associated -relationship between serum C -reactive protein （CRP） and seizure severity in adult epilepsy patients. Methods One hundred and ninety- seven epitepsy patients after drug therapy were divided into 4 groups ： non - epileptic seizure group （ n = 70 ） , mild seizure group （ n = 48 ） , moderate seizure group （ n = 50） and severe seizure group （ n = 29）. The level of CRP in patient serum was measured at resting time of seizure. Results The levels of serum CRP inthe4 groups were （1.44 ±0.88） mg/L, （2.87±0.18）mg/L, （ 5. 34 ± 0. 20 ） mg/L and （9.63 ± 0. 64） mg/L, respectively. There were significant differences between the 4 groups tested by ONE - WAY ANOVA （F = 179.35 ,P 〈 0.01 ）. The rank positive associated -relationship existed between the serum CRP level and seizure severity （ r s = 0. 083, P 〈 0.01 ）. Conclusions The more serious seizure frequency of epilepsy patients, the higher the level of their serum CRP. Serum CRP levels may be a predictor of the severity of epileptic seizures.
出处
《中国实用医刊》
2012年第1期44-46,共3页
Chinese Journal of Practical Medicine
关键词
癫痫
C-反应蛋白
发作程度
Epilepsy
C - reactive protein
Seizure severity
