摘要
目的探讨系统性红斑狼疮(SLE)活动性同凝血与纤溶障碍的关系。方法回顾性分析661例SLE活动期和非活动期患者的凝血与纤溶障碍指标和临床表现、血常规、血沉、C反应蛋白、补体、抗ds-DNA、抗核抗体(ANA)、肝肾功能及尿常规的变化情况。结果活动期患者410例,发生凝血与纤溶障碍342例(83.42%);非活动期患251例,发生凝血与纤溶障碍56例(22.31%)。2组比较有显著性差异(P<0.01)。2组治疗前凝血与纤溶指标均有不同程度障碍,组间比较有显著性差异(P<0.05),治疗后组间比较无显著性差异。重度狼疮活动组凝血与纤溶障碍发生率明显高于中度活动组,中度活动组明显高于轻度活动组,三者比较有显著性差异(P均<0.01)。结论 SLE患者活动期发生凝血与纤溶障碍率高于非活动期,其活动性程度同凝血与纤溶障碍严重程度呈正相关。SLE活动可引起凝血与纤溶障碍,凝血与纤溶障碍又可加重SLE活动。
Objective It is to investigate the relationship of erythematosus activity and blood coagulation, fibrinolysis obstruction in patients with systemic lupus erythematosus （SLE）. Methods The total 661 patients with SLE in active stage and no active stage before and after treatment were observed for blood coagulation and fibrinolysis, clinical manifestation, blood and urine routine, erythrocyte sedimentation rate （ESR）, C-reactive protein （CRP）, complement, ds -DNA, antinuclear antibody （ANA）, liver and kidney function. Results There were 410 patients with active stage, and their blood coagulation and fibrinolysis obstruction rate was 83.42% , and 251 patients with no active stage was 22.31%. There were significant differences between them （P 〈 0. 01 ）. The blood coagulation and fibrinolysis obstruction had statistical difference before treatment and had no difference after treatment between them. The happen rate of blood coagulation and fibrinolysis obstruction of serious SLE activity group was higher than medium activity group, and medium SLE activity group was higher than slight SLE activity group. Conclusion The obstruction rate of blood coagulation and fihrinolysis in active stage is higher than that in no active stage; the activity is positively correlated with the obstruction of blood coagulation and fibrinolysis. Lupus activity may be an important factor of obstruction of blood coagulation and fibrinolysis, and the obstruction of blood coagulation and fibrinolysis may result in serious lupus activity.
出处
《现代中西医结合杂志》
CAS
2012年第3期233-234,共2页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
狼疮性肾炎
活动指标
凝血与纤溶障碍
systemic lupus erythematosus
activity index
obstruction of blood coagulation and fibrinolysis
