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颈内动、静脉血药浓度平衡时不同麻醉深度丙泊酚对犬脑不同区域谷氨酸的影响 被引量：3

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摘要 目的:观察颈内动、静脉血药浓度平衡时不同麻醉深度丙泊酚对犬脑不同区域谷氨酸(GLU)的影响。方法:12只12～18个月健康杂种犬,体重10～12kg,随机分为浅、深麻醉组(n=6),分别以丙泊酚5.5和7mg/kg静脉注射,续以55和70mg/(kg.h)恒速静脉输注维持50min,取颈内动、静脉血各2mL后处死,取背侧丘脑、上丘脑、后丘脑、下丘脑、底丘脑、额叶、顶叶、颞叶、枕叶、海马、扣带回、小脑、中脑、桥脑、延髓、颈髓组织。用高效液相色谱(HPLC)测血浆丙泊酚浓度和脑组织GLU含量。结果:颈内动、静脉血浆丙泊酚浓度:浅麻醉组分别为(3.00±0.31)μg/mL和(3.10±0.51)μg/mL(P>0.05);深麻醉组分别为(6.41±0.05)μg/mL和(6.40±0.11)μg/mL(P>0.05)。深麻醉组各区域脑组织GLU含量明显低于浅麻醉组(P<0.01)。两种麻醉深度下,下丘脑GLU变化率(88.76±0.04)%,明显高于其他脑区(P<0.05)。结论:丙泊酚恒速静脉输注50min时,两组犬脑动、静脉血药浓度均达到平衡;丙泊酚麻醉深度与GLU的变化相关,下丘脑及其GLU的变化在丙泊酚麻醉中发挥重要的作用。
作者 郭高锋 林春水 古妙宁 汪燕 周枝凤 陈莺
机构地区 南方医科大学南方医院麻醉科 南方医科大学公共卫生与热带医学学院
出处 《实用医学杂志》 CAS 北大核心 2012年第1期58-60,共3页 The Journal of Practical Medicine
基金 广东省自然科学基金资助项目(编号:10151051501000104)
关键词 二异丙酚 谷氨酸 犬 脑 血药浓度
分类号 R614 [医药卫生—麻醉学]
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参考文献16

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共引文献21

同被引文献58

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实用医学杂志
2012年 第1期

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