摘要
目的:观察具有益气活血通痹作用的中药超微细粉小复方对冠脉结扎大鼠血清SOD、MDA的影响。方法:通过冠脉结扎建立大鼠心肌缺血模型,63只大鼠随机分假手术组(Sham)、模型组(Model)、中粉组(Z)、超微细粉组(X)、煎剂组(J)、麝香保心丸组(SX)等7组,灌胃14天。观察心电图和血清SOD、MDA的变化。结果:益气活血通痹小复方能够降低心电图J点升高程度,升高SOD,降低MDA。结论:益气活血通痹小复方能够减轻心肌的缺血性损伤,可能与其调节血清SOD、MDA,减轻缺血后的氧化应激反应,从而发挥抗心肌缺血的作用有关。
Objective：To observe the effect of Yiqi Huoxue Tongbi small micropowder compound recipe on the Superoxide dismutase,Malonaldehyde in rats with myocardial schemia.Methods：63 SD rats were divided into 7 groups randomly：sham group,model group,thick powder group（C）,mediate powder group（Z）,micropowder group（X）,decoction group（J） and Shexiang Baoxin Pills group（SX）.Rats were fed 14 days,SOD and MDA contents in plasma were observed.Results：Yiqi Huoxue Tongbi compound recipe could obviously decrease J point raise,increase SOD level and decrease MDA level.Conclusion：Yiqi Huoxue Tongbi compound recipe has the effect of releasing myocardial schemia injury,maybe it is because of regulating the Serum SOD,MDA to antagonize myocardial schemia.
出处
《中华中医药学刊》
CAS
2012年第1期118-120,共3页
Chinese Archives of Traditional Chinese Medicine
基金
上海市引进技术的吸收与创新计划资助项目(YY-16)
关键词
超微细粉小复方
益气活血通痹
冠脉结扎
超氧化物歧化酶
丙二醛
small micropowder compound recipe
Yiqi Huoxue Tongbi
coronary artery ligation
Superoxide dismutase
Malonaldehyde
