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254例联合用药所致肝损害的临床分析 被引量:4

The Clinical Analysis of 254 Cases Liver Damage Caused by Drug Combination
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摘要 目的通过分析联合用药所致肝损害的临床特点,提高对该类肝损的认识。方法从江苏省药品不良反应数据库中提取出254例联合用药所致的肝损害病例,回顾性分析其临床表现、实验室检查、治疗措施、合并用药数、怀疑药品分类等。结果 2种药品并用160例,3种药品并用62例,4种药品并用26例,5种药品并用5例,6种药品并用1例;诱发肝损害的可疑药物主要是抗结核病药56例(22.05%),抗肿瘤药47例(18.50%),中药31例(12.20%);主要临床表现为转氨酶等指标异常,大部分经停用可疑药品及护肝利胆治疗后可好转或治愈,死亡2例(0.79%)。结论严格掌握联合用药的适应症,熟悉各药品的成分、代谢特点等,确保安全、合理用药。 Objective Through the clinical characteristics analysis of the liver damage caused by the combination, improve the understanding of the liver damage. Methods To extract 254 cases liver damage by combination from the database of Center for ADR Monitoring of Jiangsu, and analyse the clinical manifestations, laboratory examination, treatment measures, drug combination number, suspected drug classification, etc. Results There are 160 cases of 2 drugs combination, 62 cases of 3 drugs combination, 26 cases of 4 drugs combination, 5 cases of 5 drugs combination, only 1 case of 6 drugs combination. The suspicious drugs inducing liver damage are mainly antituberculosis medicines(56 cases, 22.05%), antitumor medicines(47 cases, 18.50%) and traditional Chinese medicines(31 cases, 12.20%). Major clinical manifestation is the abnormal level of transaminase, etc., most of the patients can be better or cured after treatment except for 2 death cases(0.79%). Conclusion Strictly master the indications of combination, and be familiar with the drugs' ingredients, metabolic features and the like to ensure safe and rational drug use Key words:
作者 徐厚明 史娟
出处 《中国药物警戒》 2012年第1期54-57,共4页 Chinese Journal of Pharmacovigilance
关键词 联合用药 肝损害 临床分析 combination liver damage clinical analysis
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