摘要
目的:观察静脉滴注地尔硫卓治疗不稳定型心绞痛的临床疗效。方法:50例口服硝酸酯类药物治疗效果不佳的不稳定型心绞痛患者静脉滴注地尔硫卓,剂量为5.0μg/(kg.min)。如心绞痛发作消失或不发作即按此剂量维持48 h后改口服,如果仍有心绞痛发作则认为治疗无效,需更改治疗方案。结果:50例不稳定型心绞痛患者中,有效46例,有效率92.00%,在治疗中心率、血压逐渐下降,有助于控制心绞痛。治疗过程中5例出现窦性心动过缓,4例出现低血压,地尔硫卓减量后均好转,无其他不良反应。结论:地尔硫卓可以作为治疗不稳型性心绞痛,尤其是硝酸酯类药物疗效不佳的一线药物。
Objective To observe the effect of administering diltiazem（Dil） intravenously on patients with unstable angina（UA）.Method Total 50 hospitalized UA patients who had poor response to the nitrates were administered intravenously of Dil with a dosage of 5 μg/（kg·min）.Corresponding doses of Dil in oral formulation were prescribed if the angina kept in silence for more than 48 hours at this dosage and inefficiency was defined as uncontrolled angina attacking at this dosage.Besides the symptom,heart rate,blood pressure,ECG and some side effects such as hypotension,arrhythmias and heart failure were also observed during the trail.Results Angina attack was controlled in 46 cases.The cumulative effective rate was 92.00%.The heart rate,blood pressure,or the rate pressure product were decreased gradually during the medication,which contributed to the angina controlling.During the trail,except five cases of sinus bradycardia and four cases of low blood pressure made it after reduce of Dil dosage.Conclusion Dil could be favorable drug to unstable angina patients,especially the nitrate-inefficacious ones.
出处
《吉林医学》
CAS
2012年第1期27-29,共3页
Jilin Medical Journal
