摘要
目的测定近交系大鼠MIJ、HFJ和封闭群Wistar大鼠的脏器系数、体温、呼吸频率、肠管长度,观察两个近交系大鼠的生理表型。方法 采用常规方法对大鼠脏器系数、体温、呼吸频率及肠管长度进行测定,并对HFJ、MIJ、Wistar大鼠三者间进行比较。结果①体重:HFJ、MIJ、Wistar大鼠同性别间比较差异无显著性。②脏器系数:HFJ与Wistar大鼠雄性间心脏、肺,雌性间子宫、肝;MIJ与Wistar大鼠雄性间肺、脾,雌性间脑、脾,差异均有显著性。HFJ与MIJ大鼠雄性间脑,雌性间脑和脾差异有显著性。HFJ大鼠不同性别间肝、脑、眼球差异有显著性。MIJ大鼠不同性别间,脑、心脏、肾、肺、脾和眼球差异均有显著性。③体温:HFJ雌性大鼠明显高于Wistar雌性,雄性间差异无显著性。HFJ大鼠雌性高于雄性,差异有显著性。④呼吸频率:HFJ雌性大鼠低于同性Wistar大鼠,MIJ大鼠雌性和雄性均高于同性别Wistar大鼠,差异有显著性。⑤肠管长度:HFJ与Wistar同性别间比较,肠管总长和小肠差异有显著性。MIJ与Wistar大鼠雄性间肠管总长、大肠、小肠、盲肠差异均有显著性,雌性间肠管总长、小肠、盲肠差异有显著性。HFJ与MIJ大鼠同性别间差异均无显著性,不同性别的HFJ和MIJ的肠管总长、大肠和小肠差异有显著性。结论 MIJ和HFJ近交系大鼠的脏器系数、体温、呼吸频率、肠管长度都各有其独特的生理概貌。
Objective To determine the organ coefficient,body temperature,respiratory rate and intestinal length of the inbred strains of MIJ rats,HFJ rats and closed colony of Wistar rats,and to observe the physiological phenotypes of the inbred strains of rats.Methods The animals＇ organ coefficient,body temperature,respiratory rate and intestinal length were routinely measured.Comparison was made between HFJ and MIJ rats,HFJ and Wistar rats or MIJ and Wistar rats,respectively.Results（1） Body weight： no significant differences were observed in the same sex of HFJ,MIJ and Wistar rats.（2） There were significant differences of the organ coefficients of the heart and lung between the male Wistar and HFJ rats,that of the uterus and liver between the female Wistar and HFJ rats,that of the lungs and spleens of the male MIJ and Wistar rats,that of the brains and spleens of female MIJ and Wistar rats,and that of the brain of male HFJ and MIJ rats.There was also significant difference between the organ coefficients of the brain and spleen of the female HFJ and MIJ rats,that of the liver,brain and eyeball of the male and female HFJ rats,that of the brain,heart,kidneys,lungs,spleen and eyeball of the male and female MIJ rats.（3） Body temperature： The body temperature of the female HFJ rats was significantly higher than that of female Wistar rats,but no significant differences were observed between the male rats.The body temperature of female HFJ rats was significantly higher than that of the males.（4） Respiratory rate： The female HFJ rats had a lower respiratory rate than that in female Wistar rats,and the respiratory rates of the male and female MIJ rats were higher than that of the same gender of Wistar rats.（5） Intestinal length： There were significant differences between the total intestinal length and the length of small intestine of the HFJ and Wistar rats of the same sex,the total intestinal length,the large intestinal length,the small intestinal length,and the cecum length of the male MIJ and Wistar rats,and between the total intestinal length,small intestinal length,cecum length of the female MIJ and Wistar rats.There were significant differences between the total intestinal length,large intestinal length and small intestinal length of male and female HFJ and Wistar rats,but no significant differences between the intestinal length of HFJ and Wistar rats of the same sex.Conclusions All the organ coefficients,body temperature,respiratory rate,intestinal length of the inbred MIJ and HFJ rats have their own unique physiological profiles.
出处
《中国实验动物学报》
CAS
CSCD
2011年第6期539-543,共5页
Acta Laboratorium Animalis Scientia Sinica
基金
河北省科技支撑计划重点项目(09276426D)
河北省科技攻关计划项目(07275503)
关键词
近交系HFJ大鼠
近交系MIJ大鼠
生理数据测定
观察分析
Inbred strain of HFJ rats
Inbred strain of MIJ rats
Determination of physiological data
Anatomical data
