摘要
目的:分析比较甲磺酸氨氯地平2种给药方案治疗轻、中度高血压患者的降压疗效。方法:回顾性分析广州医学院第三附属医院2009年服用甲磺酸氨氯地平高血压的住院患者122例,根据用药方案不同分为A组和B组。A组为服用甲磺酸氨氯地平10 mg,qd,早上服用。B组为服用甲磺酸氨氯地平为5 mg,bid,早晚服用。比较2组治疗方案对血压、心率、不良反应的影响。结果:2种给药方案疗对血压影响无显著性差异(P>0.05),A组的总体血压稳定性较B组差,降压幅度较大,B组降压幅度较小,但血压稳定性好。2种给药方案对心率的影响有显著性差异(P<0.05),A组治疗后心率变化大于B组,2种给药方案与疗效彼此独立,降压疗效相当(P>0.05),2种用药方案疗效与年龄、性别无关(P>0.05),不良反应轻微。结论:甲磺酸氨氯地平2种给药方案疗效相当,可根据患者的病情选择合理的给药方式,值得临床借鉴和使用。
OBJECTIVE To compare the effects of amlodipine mesylate 10 mg （A） and 5 mg （B） in essential hypertension. METHODS Clinical data of 122 patients with hypertension were retrospectively analyzed. The patients were divided into two groups according to the dosage regimen. The effects on blood pressure, heart rate and adverse reaction were compared. RESULTS There was no significant difference in the blood pressure（P〉0. 05）. The blood pressure of B group was more stable than A group. There was significant difference in heart rate（P〈0. 05）. Age and sex were not correlative with the dosage regimen. The adverse reactions in two groups were mild. CONCLUSION The two dosage regimes is therapeutic equivalence; can choose A or B reasonably according to the pathogenetic condition.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2012年第2期133-135,共3页
Chinese Journal of Hospital Pharmacy
关键词
甲磺酸氨氯地平
高血压
疗效比较
amlodipine mesylate
hypertension
efficacy comparison
