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IL-23／Th17轴与自身免疫性疾病 被引量：8

IL-23/Th17 pathway and Autoimmune Diseases
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摘要 既往研究认为，自身免疫性疾病主要足Th1／Th2平衡失调所致，但就Th1细胞亚群的研究结果并不能完全解释自身免疫性疾病的发病机制。Th17细胞是新发现的CD4^＋辅助性T细胞亚群，IL-23是Th17细胞赖以存在，并维持其稳态及扩增，促进其分泌IL—17的必需细胞因子。目前认为，越来越多的研究表明，IL-23／Th17轴参与了多种自身免疫性疾病的病理过程。 Previous studies have indicated the role of the Thl/Th2 in autoimmune diseases. However, studies on Thl cells could not clarify the pathogenesis of autoimmune diseases. Thl7 cells are nowly found CD4^＋ T helper cells. Interleukin-23 is the essential cytokine which maintains and promotes,amplification of IL- 17 secreting the Thl7 ceils. Recent data suggest that the IL-23/Th17 pathway is involved in the pathogenesis of autoimmune diseases .
作者 杨帆 伍伟锋
机构地区 广西医科大学第四附属医院柳州市工人医院心内科
出处 《国际免疫学杂志》 CAS 2012年第1期61-63,共3页 International Journal of Immunology
关键词 IL-23/Th17轴 自身免疫 IL-23/Th17 pathway Autoimmune diseases
分类号 R593.2 [医药卫生—内科学]
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参考文献22

  • 1Langrish CL, Chen Y, Blumenschein WM, et al. 1L-23 drives apathogenic T cell population that induces autoimmune inflamma- tion. J Exp Med, 2005, 201 (2) :233-240.
  • 2McGeachy.MJ, Cua, DJ. The link between IL-23 and Thl7 cell- mediated immune pathologies. Seminars in Immunology,2007,19 (6) :372-376.
  • 3Metawi SA, Abbas D, Kamal MM, etal. Serum and synovial fluid levels of interleukin-17 in correlation with disease activity in patients with RA. Clin Rheumatol, 2011, 30 (9) : 1201-1207.
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  • 7Li Y, Wang H, Long Y, et al Increased memory Thl7 cells in patients with neuromyelitis optiea and multiple sclerosis. J Neuroimmunol, 2011, 234(1-2):155-160.
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国际免疫学杂志
2012年 第1期

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