摘要
目的研究急性冠脉综合征（ACS）患者血小板微粒（PMP）的数量变化及其与IL-6的相关性。方法选取26例ACS，包括12例心肌梗塞（MI）和14例不稳定性心绞痛（UA）患者，12例稳定性心绞痛（SA）和12例健康人作为研究对象。采用流式细胞术对血浆中的PMP数量进行检测，同时采用酶联免疫吸附法（ELISA）测定血清IL-6水平。结果4组患者PMP数量比较差异有统计学意义（F=28．05，P〈0．001）。MI组[（6．82±2．12）×10^2／ml]或UA组[（6．09±1．44）×10^5／ml]的PMP数量分别与SA组[（2．34±1．33）×10^5／ml]比较均显著增高（均P〈0．001）；MI组或UA组的PMP数量分别与正常对照组[（2．27±1．40）×10^5／ml]比较均显著增高（均P〈0．001）。PMP与IL-6比较差异有统计学意义（r=0．567，P〈0．001）。结论PMP可能有助于ACS患者血栓的形成和增强炎症性反应。
Objective To investigate alterations in the amount of platelet microparticles （PMPs） in patients with acute coronary syndrome （ACS）, and to evaluate the possible relationship between PMPs and interleukin-6 （IL-6）. Method We studied 26 patients with ACS, including 12 patients with myocardial infarction （MI） and 14 patients with unstable angina （UA）, 12 patients with stable angina （SA） and 12 healthy subjects. The amount of PMPs in the plasma was measured by flow cytometry. The levels of IL-6 in the blood were determined by ELISA. Results Compared between groups, the amount of PMPs was significantly different （F=28.05, P 〈0. 001 ）. Compared with patients with SA [ （2.34 ± 1.33） ×10^5/ml], the amount of PMPs was significantly elevated in patients with MI [ （6.82 ± 2. 12）×10^5/ml] or UA [ （6.09± 1.44） ×10^5/ml] （P 〈 0. 001 ）, respectively. The amount of PMPs was significantly elevated in patients with MI or UA compared with healthy subjects [ （2.27± 1.40）×10^5/ml] （P 〈0.001 ）, respectively. The level of PMPs was significantly correlated with the level of IL-6 （r = 0. 567, P 〈 0.001 ）. Conclusion These results suggest that PMPs may contribute to the development of thrombus and enhance the inflammation in patients with ACS.
出处
《国际免疫学杂志》
CAS
2012年第1期77-80,共4页
International Journal of Immunology
关键词
血小板微粒
急性冠脉综合征
IL-6
Platelet microparticles
Acute coronary syndrome
Interleukin-6
