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表观遗传调控在糖尿病及其并发症中的作用 被引量：3

The Role of Epigenetic Regulation in Diabetes and Its Complications
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摘要 表观遗传(epigenetics)是指DNA序列不发生变化但基因表达却发生了可遗传的改变.表观遗传调控过程十分复杂,主要包括DNA甲基化、组蛋白修饰和微小RNA(miRNA)等.糖尿病是一种慢性代谢性疾病,常伴随大血管和微血管并发症.糖尿病的发生、发展不仅取决于遗传因素,而且也受到表观遗传修饰的调控.因此,对表观遗传调控的研究将为糖尿病及其并发症的预防和治疗提供新的思路和方法. Epigenetics indicates the heritable changes in gene expression without nucleotide sequence variation. The process of epigenetic regulation is very complex, which mainly includes DNA methylations, histone modifications and miRNA. Diabetes is a chronic metabolic disease accompanied with macrovascular and microvascular complications. The development of diabetes not only depends on genetic factors, but also is regulated by epigenetic regulation. Therefore, further exploration into epigenetic regulation will provide new ideas and methods to the prevention and treatment for diabetes and its complications.
作者 凌宏艳 胡弼 奉水东 廖端芳 文格波
机构地区 南华大学医学院生理学教研室 南华大学基础医学博士后流动站 南华大学公共卫生学院流行病学教研室 湖南中医药大学药学院 南华大学附属第一医院临床研究所
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2012年第1期14-21,共8页 Progress In Biochemistry and Biophysics
基金 国家自然科学基金(81000328 30971170) 南华大学博士科研启动基金(2010XQD39)资助项目~~
关键词 表观遗传调控 糖尿病 糖尿病并发症 epigenetic regulation, diabetes, diabetic complications
分类号 R587.1 [医药卫生—内分泌]
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参考文献61

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二级参考文献35

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共引文献30

同被引文献40

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生物化学与生物物理进展
2012年 第1期

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